... (CNS), determine the pharmacokinetic and pharmacodynamic properties of novel therapeutics and evaluate the CNS penetration or toxicity of compounds. However, a review of the literature reveals inconsistent operating procedures from one study to another. While this fact does not invalidate results per...

...: The approach was based on P-gp knockout mice which were compared with wild-type mice under several conditions. In vivo pharmacokinetic and microPET investigations were carried out. Results: All analyses showed that [ 18 F]MH.MZ entered the brain and was sensitive to P-gp transport. In P-gp knockout mice, brain...

...C.B. Eap; S. Laurian; A. Souche; L. Koeb; P. Reymond; T. Buclin; P. Baumann The pharmacokinetics and pharmacodynamics (waking EEG) of 75 mg trimipramine taken orally were determined in two healthy volunteers on two separate occasions, once without and once after comedication with 2 × 50 mg...

...Philippe Jacqmin; Marc Ansseau The pharmacokinetic profiles of oral and sublingual administrations of prazepam 20 mg to 5 normal volunteers were compared in order to explain the clinical observation that sublingual prazepam appears to exhibit sedative properties when compared to the same dose...

.... A sustained-release form might be useful to decrease the frequency of administration. In our study, the pharmacokinetics of sustained-release form containing 300 mg viloxazine were compared with 300 mg conventional viloxazine in 11 normal volunteers (6 women, 5 men). Wide interindividual variations were...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Antidepressants Pharmacokinetics Plasma levels Amitriptyline Imipramine Ncuropsychobiology 8: 73-85 (1982) Tricyclic Antidepressant Plasma Levels: the State of the Art...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Benzodiazepines Oxazepam Pharmaco-EEG Pharmacokinetics Generalized anxiety disorder Anxiety rating scales Visual analogue scales Neuropsychobiology 12: 255-259 (1984...

...Seppo Kähkönen; Edwin E. Zvartau The cardiovascular effects and pharmacokinetics of a single dose (20 mg sublingually) of isosorbide dinitrate (ISDN) were studied in 9 alcohol-dependent men during alcohol withdrawal syndrome (AW) on day 1 and after the resolution of AW on day 10. At the onset of AW...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Shift work Circadian rhythms Sleep disorders Vigilance Neuroactive drugs Hormones Performance Health risks Pharmacokinetics Brain dynamics Pharmacoelectroencephalography...