... different phases of tolerance and dependence to morphine and to determine the effects of inhibition of endogenous hydrogen sulfide production on the development of tolerance and dependence. Methods: Morphine tolerance and dependence was developed by subcutaneous injection of morphine (10 mg/kg) twice daily...

... treatment (MMT) in morphine-withdrawn rats. Methods: Male Wistar rats (170 ± 10 g) were injected with bi-daily doses (10 mg/kg, 12-h intervals) of morphine for 14 days. Rats receiving MMT were reared in the standard environment (SE) or EE during 30 days of morphine withdrawal. Then, the rats were tested...

...Carina Graversen; Anne Estrup Olesen; Camilla Staahl; Asbjørn Mohr Drewes; Dario Farina Background and Aims: Current findings on altered evoked potentials (EPs) caused by morphine are based on common alterations for a group of subjects after drug administration. However, this ignores the analysis...

...Jonathan J. Lipman; Stephen Tolchard The effects of morphine (5 mg/kg) and amphetamine (5 mg/kg) were examined on relative regional cerebral glucose uptake (RrCGlu), surveyed in 20 brain areas in the rat. No relationship was found between drug effects on the cortical RrCGlu and the quantitative...

...Jeffery Feigenbaum; Joseph Yanai Morphine has been universally assumed to act solely on opiate receptors, and predominantly on µ receptors. In consonance with this, several studies have demonstrated that opiate µ agonists and dopaminergic agonists and antagonists are incapable of binding each...

...R. Tissot Microinjections of morphine in optimal doses into the medial thalamus (40 µg) and periaqueductal gray matter (10–20 µg) produce slow-wave sleep with abondant spindles, in addition to analgesia. Like analgesia, the sleep-inducing effect is blocked by naloxone (1 mg/kg i.v., l60 µg i.c...

...L. Branchey; A.J. Friedhoff Tyrosine hydroxylase was measured in the caudate of rats subjected to two series of implantations of morphine pellets and in rats subjected to implantations of placebo pellets followed by morphine implantations. The results suggest the existence of a ‘biological memory...

...Stephen Miksic; Nelson Smith; Robert Numan; Harbans Lai Following a 7-day baseline period, five male hooded rats were injected daily with a constant dose (20 mg/kg) of morphine sulfate. Immediately following the injections they were taken to a sound-attenuated room and exposed to a 5,000 cps tone...

... were: hypnosis (induced by two different video tapes), acupuncture (at specific and unspecific loci, with and without electrical stimulation of the needles), morphine and ketamine. Evaluation of clinical parameters included the subjective experience of pain intensity, blood pressure, pulse, temperature...

..., were compared for their voluntary intake of ethanol, nicotine, cocaine and morphine. Younger BNR self-administered the same amounts of all 4 substances as did the younger WKR suggesting a similar genetic basis for all drugs at this age. Older BNR consumed less ethanol and nicotine but equal amounts...

...C. Robert; L. Stinus; A. Limoge Morphine pellets (2 × 75 mg) were subcutaneously implanted in rats and vigilance states (wakefulness, slow wave sleep and paradoxical sleep) were observed during ten days. Significant impairment of each vigilance state distribution appeared during the first days...