... challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Accordingly, a combination of these approaches should be particularly suited to investigate cognition-emotion interaction. Methods: Seventy five healthy subjects were investigated in a double-blind...

...Goyo Nagai; Kazuo Mihara; Shoko Kagawa; Akifumi Nakamura; Takeshi Suzuki; Kenji Nemoto; Tsuyoshi Kondo Background/Aims: The present study prospectively examined whether or not a partial response at week 4 predicts subsequent response at week 8 during lamotrigine augmentation therapy in 51 (16 males...

...Shoko Kagawa; Kazuo Mihara; Takeshi Suzuki; Goyo Nagai; Akifumi Nakamura; Kenji Nemoto; Tsuyoshi Kondo Background/Aims: Serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) were prospectively monitored in relation with therapeutic response to lamotrigine augmentation...

...A. van Wieringen; C.D. Binnie; J.W.A. Meijer; A.W. Peck; J. de Vries Phenytoin and lamotrigine (a new antiepileptic drug with an animal experimental profile resembling phenytoin) have closely similar effects on the quantitative pharmaco-electroencephalogram. These characteristics do not provide...

...J.M. Langosch; X.-Y. Zhou; H. Grunze; J. Walden This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs. The concentration response curves showed...

...Heinz Grunze; Jörg von Wegerer; Robert Greene; Jörg Walden Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously...

...Xinmin Xie; Russell Hagan Several clinical studies have investigated the use of the anticonvulsant lamotrigine (LTG) as a treatment for bipolar affective disorder. Evidence suggests that this drug may have a broad spectrum of utility in this illness, having both mood-stabilising (antimanic...

...Andreas Erfurth; Benedikt Amann; Heinz Grunze The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case...

...I.N. Ferrier The anticonvulsants carbamazepine and sodium valproate have efficacy in hypomania, bipolar depression and in the prophylaxis of bipolar disorder. This paper reviews published evidence on the effects of the new anticonvulsants gabapentin and lamotrigine in bipolar disorder...

...Andreas Erfurth; Jörg Walden; Heinz Grunze There is accumulating evidence for the efficacy of lamotrigine in the treatment of bipolar disorder, including bipolar depression, both as monotherapy and in combination with sodium valproate. We present the cases of 3 female patients admitted to our...

... of other psychotropic medications and a worsening of psychopathology. First data indicate a good antimanic and antidepressive efficacy of the new antiepileptic drug lamotrigine. 23 10 1998 1998 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication...

... cycling. During the development of the antiepileptic, lamotrigine, the drug was observed to improve mood, alertness, and social interactions in some patients with epilepsy. These early observations provided the rationale for investigations into lamotrigine’s potential efficacy in bipolar disorder...