...Michele Fabrazzo; Palmiero Monteleone; Vincenzo Prisco; Francesco Perris; Francesco Catapano; Alfonso Tortorella; Alessio Maria Monteleone; Luca Steardo; Mario Maj The effects of olanzapine and haloperidol on metabolic parameters in bipolar patients have been evaluated much less comprehensively...

... can predict subsequent non-response. Methods: 86 acutely psychotic patients treated with haloperidol were studied. Results: A PANSS reduction ≤16% at 1 week predicts non-response at 3 weeks of treatment (specificity 92%, sensitivity 82%). Conversely, a PANSS reduction ≥23% at 1 week of treatment...

... of quetiapine (QUE), olanzapine (OLA) and haloperidol (HAL), at final concentrations corresponding to doses used for treatment of acute episodes of schizophrenia, on plasma lipid peroxidation in vitro, measured by the level of thiobarbituric acid-reactive substances (TBARS). Methods: Blood from 30 healthy...

... mg/kg, 21 days) on CRF mRNA expression was determined using in situ hybridization of tissue sections from the rat hypothalamic PVN. Haloperidol (1.0 mg/kg, 21 days) was used for comparison. Results: Haloperidol increased the expression of CRF mRNA in the PVN under basal conditions, whereas...

...Minda R. Lynch When treated chronically with haloperidol, rats show progressively enhanced behavioral suppression, mimicking the delay of onset seen clinically with neuroleptics. To investigate potential neurochemical mechanisms underlying this delay, low-dose apomorphine treatment was administered...

...Wen-Ho Chang; Michael W. Jann; Teh-Soon Chiang; Hsin-Nan Lin; Wei-Herng Hu; Ching-Paio Chien Haloperidol (HL) and reduced haloperidol (RH) plasma concentrations were measured in geriatric patients (n = 45) and schizophrenic patients (n = 8). In the elderly patients, HL doses were 1–4 mg/day while...

...-associated behaviour. These observations prompted us to investigate whether an anti-arousal drug would induce an opposite effect. We have reported that the administration of haloperidol (HA), a neuroleptic drug clinically used for psychiatric disorders, decreases NGF levels in the hypothalamus of adult male...

...Michael W. Jann; Brian L. Crabtree; Wesley M. Pitts; Francis Lam; Gary Carter Thirty six schizophrenic patients were randomly assigned to placebo or haloperidol treatment for 6 weeks. Blood samples to measure plasma alpha-one acid glycoprotein (AAG), haloperidol and reduced haloperidol...

... as serum prolactin levels. Six patients were treated with haloperidol and 12 with sulpiride; after 2 months sulpiride was administered at half the daily dose to 6 patients previously treated with the same drug. Clinical evaluation showed that sulpiride treatment led to a greater improvement compared...

...Kazuhiko Iwahashi; Hirohito Yoneyama; Taira Ohnishi; Kazuhiko Nakamura; Ryosuke Miyatake; Hiroshi Suwaki; Kiyoshi Hosokawa; Yoshiyuki Ichikawa The effect of a neuroleptic, haloperidol (HP), on nitric oxide formation catalyzed by neuronal nitric oxide synthase (n-NOS) in the porcine brain...

...Nobutaka Motohashi; Mizuo Takashima; Nobuko Malaga; Toru Nishikawa; Atsuko Ogawa; Shuzo Watanabe; Michio Toru We have examined the effects of sulpiride, oxypertine and haloperidol on the bevavioral and biochemical dopamine receptor function in the rat striatum. Although acute treatment...

...Michel Bourin; Lionel Poisson; Claude Larousse Two psychopharmacological tests which usually predict neuroleptic activity were conducted after joint administration of piracetam and three neuroleptics (haloperidol, fluphenazine and sulpiride) chosen for their different chemical classes...

...Avtar Saran; Obo Addy; Roland H. Foliart; Daniel S.P. Schubert; Angelos Halaris This prospective study was undertaken in order to establish indices of possible neurotoxicity due to the combination of lithium with haloperidol and a combination of lithium with other neuroleptics. Twenty-one subjects...

... neuroleptization Titration technique Haloperidol Chlorpromazine Abstract. Years of experience have indicated that the widespread and frequent use of rapid tranquilization is not based on demonstrated efficacy. Multiple high-dose administration of neuroleptics parenterally does not produce rapid relief...

...C. Bouras; P. Schulz; J. Constantinidis; R. Tissot Rats received 10 mg/kg/day of haloperidol during up to 9.5 weeks. Substance P, Leu- and Met-enkephalins, were studied in brain using immunohistochemical methods. Haloperidol modified the peptides immunoreactivity in most brain areas. The time...

...Thomas Rammsayer The effects of 3 mg haloperidol and 125 mg Madopar® on duration discrimination (DD) as well as reaction times were tested in a placebo-controlled, double-blind crossover study with 24 healthy male volunteers. Performance in DD was significantly impaired under haloperidol compared...

...Gérard Emilien Five different classes of drugs (clonidine: 0, 0.10, 0.30, 0.50 mg/kg; yohimbine: 0, 2, 4, 8 mg/kg; haloperidol: 0, 0.02, 0.04, 0.08 mg/kg; piracetam: 0, 150, 300, 600 mg/kg, and eserine: 0, 0.10, 0.30, 0.50 mg/kg) were studied on two cortical EEG derivations as well as a deep...

...P. Rinieris; J. Hatzimanolis; M. Markianos; C. Stefanis Fifteen male paranoid schizophrenics underwent an initial 4-week therapy with haloperidol 7.5 mg/day, and a subsequent 4-week treatment with haloperidol 15 mg/day, p.o. (group I). Another 15 male paranoid schizophrenics received an initial 4...

... was treated with 10 mg haloperidol/day for the duration of 14 days, and another group of 16 patients was treated with 20 mg haloperidol/day for the same period. 16 patients of a third group were treated for 14 days with an individual haloperidol dose adapted to the psychopathological findings. Patients were...

...Robert J. Carey; Susan Kenney The present report presents evidence that operant conditioning processes may contribute to hypokinetic effects in rats induced by repeated haloperidol (HAL) treatments. Twenty-four male Sprague-Dawley rats were subdivided into three equal groups and given 9 daily...