.... This study aimed to investigate the antidepressant effects of forced running on chronic unpredictable mild stress (CUMS) mice by examining the impact on hippocampal HMGB-1. Methods: The experiment included a comparison with the traditional broad-spectrum antidepressant fluoxetine to evaluate the potential...

... activity in healthy rats. Few studies have compared acute and chronic actions of insulin with antidepressants in healthy rats. Methods: We hypothesized that if insulin exerts a true anti-immobility action, then its effects must be comparable to fluoxetine in both a 1-day treatment regimen and a 21-day...

...Paolo Castrogiovanni; Angela Di Muro; Donatella Marazziti We evaluated platelet 3 H-imipramine ( 3 H-IMI) binding parameters (B max and K d ) at baseline (t₀) and 2 months after (t 1 ) treatment with fluoxetine in a group of outpatients affected by a major depressive episode, according to DSM-IIIR...

...F. Brambilla; A. Draisci; A. Peirone; M. Brunetta Twenty-two female patients with anorexia nervosa, restricted type, 14–35 years old, were treated with a 4-month course of combined cognitive-behavioral therapy, nutritional counselling and antidepressant drugs (nortriptyline for 7, fluoxetine for 15...

...F. Brambilla; A. Draisci; A. Peirone; M. Brunetta Thirteen women with anorexia nervosa, binge-eating/purging type (AN-BP), 17–43 years old, were treated with a 4-month course of combined cognitive-behavioral, nutritional and antidepressant therapy (7 with amineptine and 6 with fluoxetine). Patients...

...S. Vandel; G. Bertschy; B. Bonin; S. Nezelof; T.H. François; B. Vandel; D. Sechter; P. Bizouard After a review of a pharmacokinetic interaction between tricyclic antidepres-sants (TCA) and fluoxetine the authors report their own data. They confirm the existence of an interaction of TCA...

... is not yet completely understood. In this study, we investigated plasma concentrations of norepinephrine, epinephrine and dopamine after acute and chronic administration of fluoxetine in depressive patients. Twelve patients affected by major depression received a single oral dose of fluoxetine in the morning...

...) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connected with the ventral tegmental area (VTA). A single injection of clomipramine or fluoxetine did not modify the firing rate of NAcc neurons as compared with the control group, whereas...

... administration, the effects of chronic treatment in animals are likely to be of greater clinical relevance than acute drug effects. Besides, little effort has been made to examine whether these effects interact with stressful situations, such as isolation. We have therefore examined the effects of fluoxetine...

... compared the effects of three antidepressants, fluoxetine, tianeptine and clomipramine after single and repeated application as well as after 1 week of withdrawal on the P300 and N200 waves in an auditory ‘odd-ball’ paradigm in three parallel groups of 10 healthy volunteers. Following single administration...

..., an indoleamine implicated in the pathophysiology of affective disorders, enhances NKCA in vitro and lymphocytes possess serotonin transporters and receptors. The present study evaluated NKCA in depressed outpatients before and during treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine...

... population and to investigate possible differences between fluoxetine and dothiepin in their effects on 24-hour behavioural activity monitored for the first 10 days of treatment. Patients taking dothiepin (75 mg rising to 150 mg in the second week, nocte) were found to be significantly (p < 0.05) less...