... early in the morning. This pattern of the 24-hour rhythm of plasma NA levels was similar to that of serum dopamine-β-hydroxylase (DBH) levels. After oral administration of fusaric acid, a DBH inhibitor, the rhythm changed, and plasma NA levels increased at 3 h and returned to the initial level at 23 h...

...E. Strandman; L. Wetterberg; C. Perris; S.B. Ross Serum dopamine-β-hydroxylase (DBH) activity was tested in 160 psychiatric patients suffering from affective disorders. The patients were divided into subgroups according to strict diagnostic criteria and clinical state at the time of the examination...

.... The results are presented and discussed in regard to the significance of the role of serotonin in depressive states and the action of thymoleptic agents. Affective illness Dopamine-β-hydroxylase MHPG CSF Synthesis inhibitors © 1976 S. Karger AG, Basel 1976 Copyright / Drug Dosage / Disclaimer...