..., the statistical analysis of such vast amounts of EEG data is complicated due to the limited number of subjects usually involved in pharmacological studies. In the present study, data from a trial aimed at comparing diazepam and placebo were used to investigate different properties of EEG mapping data...

...James F. O’Hanlon; Annemiek Vermeeren; Mir M.C Uiterwijk; Loe M.A. van Veggel; Henriëtte F. Swijgman Effects of benzodiazepine (diazepam, lorazepam) and benzodiazepine-like anxiolytics (alpidem, suriclone) and a 5-HT-3 antagonist (ondansetron) on actual driving performance were measured in three...

...M. Angélica de Souza Silva; Carlos Tomaz Recent findings indicate that the memory-impairing effects of benzodiazepines may preferentially involve the basolateral nucleus of the amygdala. To test this hypothesis we examined the effects on pretrial injection of diazepam into the central as compared...

.... Pharmaco-EEG Recording duration Spectral analysis Diazepam Pharmacoelectroencephalography Main Editor: W.M. Herrmann (Berlin) Original Paper Neuropsychobiology 1995;32:106-114 Marc Joben Hartnun Schulz Peter Jähnig Parexel GmbH, Department of Biosignal Processing, Klinikum Westend. Berlin, Germany...

...Toshihiko Kinoshita; Christoph M. Michel; Takami Yagyu; Dietrich Lehmann; Masami Saito Effects of an anxiolytic (diazepam; n = 13) and an antipsychotic (sulpiride; n = 6) on the location of EEG model sources in the frequency domain were studied in normal volunteers in 19-channel eyes-closed EEG...

...Agnieszka Unrug; Anton Coenen; Gilles van Luijtelaar Effects of alertness and memory of a single dose of diazepam (10 mg) and the central stimulant methylphenidate (20 mg) were studied in healthy volunteers. It was questioned whether opposite effects of diazepam and methylphenidate are not only...

...Magdalena Fafrowicz; Agnieszka Unrug; Tadeusz Marek; Gilles van Luijtelaar; Czeslaw Noworol; Anton Coenen Effects of the anxiolytic drugs diazepam and buspirone were studied on the reaction time of saccadic eye movements. The study was performed with 8 healthy volunteers in a double-blind, placebo...

...Agnieszka Unrug-Neervoort; Gilles Van Luijtelaar; Anton Coenen Effects of a single dose of the anxiolytic buspirone (15 mg) on memory and psychomotor performance were studied in healthy volunteers and compared to those of the classic benzodiazepine anxiolytic diazepam (15 mg). The study...

...Tadatoshi Hashimoto; Chikuma Hamada; Takeo Wada; Naohisa Fukuda Behavioral and EEG effects of 2-(7-chloro-l,8-naphthyridin-2-yl)-3-[(l,4)-dioxa-8-(azaspiro-[4.5]dec-8-yl)carbonylmethyl]isoindolin-l-one (DN-2327; 1, 5 and 20 mg/kg p.o.) were compared to those of diazepam (0.2 and 1 mg/kg p.o...

... of a patient with a schizophreniform disorder and a mild mental retardation who developed a condition which can be diagnosed either as NIC or as a mild form of NMS and has been treated successfully with a combination of amantadine (600 mg/day) and diazepam (30 mg/day). The overlapping between NIC and mild NMS...

... and the recovery of this complex across ISI appear to be rapid, reliable and sensitive measures of changes in brain function associated with drug intake. To illustrate, an acute dose of diazepam was administered orally to a small group of normal subjects. The amplitude of N 1 –P 2 was reduced and the slope...

...Martin Alda; Marta Dvořáková; Marie Pošmurová; Marie Baliková; Petr Zvoiský; Václav Filip In a study with healthy volunteers (6 monozygotic and 4 dizygotic twin pairs) we followed up diazepam serum levels and psychotropic effects of diazepam after single-dose administration. We found...

...J.P. Boulenger; K. Squillace; P. Simon; M. Herrou; P. Leymarie; E. Zarifian The effects of oral buspirone (BUS, 10 mg) and diazepam (DZP, 10 mg) were studied in 12 healthy women volunteers using subjective ratings, objective tests of psychomotor and cognitive functions and urinary dosage...

...A.A.I. Jansen; J.J. de Gier; J.L. Slangen The effects of 10 mg diazepam on signal detection theory measures (stimulus sensitivity, response bias) and reaction times were studied in a 1-hour visual signal detection task with high and low signal probability, and on performance in two short-duration...

...Terry P. Miller; Joy L. Taylor; Jared R. Tinklenberg In two studies, we studied the comparative sensitivity of different subjective and objective measures to methylphenidate (10 and 20 mg) and secobarbital (100 mg) versus placebo, and diphenhydramine (50 mg) and diazepam (10 and 20 mg) versus...

... only minor effects on the VEP-F. There was a tendency for imipramine to increase VEP-F latencies, especially the N3 peak, but had no effect on the VEP-PR. Both VEPs were unaffected by diazepam. These VEP findings add further support to the role of dopamine in the human visual system. Possible reasons...

...S. Haas; H.M. Emrich; H. Beckmann Schizophrenics treated with high doses of diazepam (150–200 mg/day) showed marked analgesia besides certain antipsychotic effects. Euphoria was noticed in some of the patients. We hypothesized that influence on the endorphin metabolism might contribute...

...Thomas-Frank Münte; Hans-Jochen Heinze; Helmut Künkel; Michael Scholz The time course of the effects of caffeine (200 mg), diazepam (8 mg) and placebo on CNV magnitude, reaction time and state of mood was investigated in normal volunteers using a double-foreperiod paradigm. CNV changes were...

...Matti Viukari; Pirkko Miettinen Diazepam 5 mg, promethazine 25 mg, propiomazine 25 mg, and placebo as sleeping aids were studied in 40 elderly inpatients. The drugs were administered in a random order, double-blind, on 21 nights. All active drugs were found effective in the mentally normal elderly...

...Gisela Erdmann; Wilhelm Janke; Sigrid Köchers; Brunhild Terschlüsen This study investigated the emotional effects of the beta-adrenergic blocking agent oxprenolol (40 mg, p.o.) and the tranquilizing agent diazepam (5 mg, p.o.) in healthy subjects under three situational conditions:an emotionally...