...Yasumasa Okamoto; Nobutaka Motohashi; Hiroshi Hayakawa; Mitsutaro Muraoka; Shigeto Yamawaki The effects of the addition of short-term lithium to long-term administration of antidepressants (clomipramine or citalopram) on the levels of 5-HT and 5-HIAA and serotonergic receptors were studied...

... responses were measured in adult rats administered with clomipramine from the 8th to the 21st day of life and exhibiting a long-lasting syndrome resembling human depression. Clomipramine-injected rats developed larger skin potential responses to sound stimulation than controls while responses to ammonia...

... (5-HT) function is unknown. Single-unit extracellular recordings were obtained from parietal cortex in rats in which dorsal raphe nucleus or cerebellar peduncle was stimulated. Results compared groups long-term treated with clomipramine (1.25 mg/kg i.p., twice a day, during 30 days) or saline (0.15...

...Carlos M. Contreras; Luisa Marván; Verónica Alcalá-Herrera Acute injection of clomipramine or a 24-hour period of sleep deprivation produces an increased firing rate in lateral septal neurons of the rat. However, it is unknown whether changes in firing rate in lateral septal neurons also appear...

...Carlos M. Contreras; Luisa Marván; Alejandro Ramírez-Morales; Armando Muñoz-Méndez Clomipramine is a serotonin reuptake blocker which produces an increased rate of firing in lateral septal neurons of the rat. However, it is unknown whether the response of dorsal raphe nucleus stimulation...

...G. Eberhard; L. von Knorring; H.L. Nilsson; U. Sundequist; G. Björling; H. Under; K.O. Svärd; L. Tysk Seventy patients with idiopathic syndromes were treated with maprotiline, a noradrenaline reuptake inhibitor, or clomipramine, a serotonin reuptake inhibitor in a 6-week, double-blind, randomized...

... reuptake inhibition, was compared with clomipramine over a period of 28 days in a daily dosage of 150 mg. Both drugs were found to be approximately equivalent and with no significant differences due to the overall assessment of the reduction of depression severity and amelioration of goal symptoms...

...V. Filip; M. Alda; I. David; J. Topinka; Z. Krištofiková; J. Dvořákoxá; D. Sztaniszláv; S. Olájos; V. Albrecht A single dose of clomipramine, 10 mg i.v., or desipramine, 25 mg i.m., was administered to seven healthy young sibling pairs in a randomized cross-over experiment. The response of serum...

...C. Faravelli; A. Brat; G. Marchetti; F. Franchi; L. Padeletti; A. Michelucci; A. Pastorino ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes...

...E. Klein; A. Hefez; P. Lavie Sleep structure of 10 endogenous depressed patients was investigated before and after clomipramine treatment. Clomipramine significantly reduced REM time, increased REM latency and induced dissociation between the tonic and phasic events of REM sleep, without affecting...

...H.M. Van Praag In 30 patients suffering from vital depression (the syndrome of endogenous depression) a negative correlation was found between the pre-therapeutic post-probenecid CSF 5-HIAA response and the therapeutic response to clomipramine (Anafranil). Clomipramine is a tricyclic antidepressant...

...) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connected with the ventral tegmental area (VTA). A single injection of clomipramine or fluoxetine did not modify the firing rate of NAcc neurons as compared with the control group, whereas...

...H. Bonilla-Jaime; S. Retana-Marquez; G. Vazquez-Palacios; J. Velázquez-Moctezuma Neonatal administration of clomipramine (CMI) in rats induces behavioral changes during adulthood, such as impairments of pleasure-seeking behaviors. However, the endocrine changes induced by this treatment...

... compared the effects of three antidepressants, fluoxetine, tianeptine and clomipramine after single and repeated application as well as after 1 week of withdrawal on the P300 and N200 waves in an auditory ‘odd-ball’ paradigm in three parallel groups of 10 healthy volunteers. Following single administration...

...Paola C. Yannielli; Lucila Kargieman; Lis Gregoretti; Daniel P. Cardinali Day-night differences in locomotor and anxiety-related behavior and brain serotonin metabolism were examined in adult Syrian hamsters that received clomipramine (15 mg/kg) or vehicle from day 8 to day 21 of life. Locomotor...