...Alicia K. Smith; Hong Fang; Toni Whistler; Elizabeth R. Unger; Mangalathu S. Rajeevan Background: There is no consistent evidence of specific gene(s) or molecular pathways that contribute to the pathogenesis, therapeutic intervention or diagnosis of chronic fatigue syndrome (CFS). While multiple...

...Audrius V. Plioplys; Sigita Plioplys Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and weakness. Ultrastructural mitochondrial abnormalities have been reported to be present in CFS patients...

...Audrius V. Plioplys; Sigita Plioplys Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in Chronic Fatigue Syndrome (CFS) patients. Previous investigations have reported decreased carnitine levels in CFS...

...Benjamin Fischler; Olivier Le Bon; Guy Hoffmann; Raymond Cluydts; Leonard Kaufman; Kenny De Meirleir Polysomnographic findings were compared between a group of patients with the chronic fatigue syndrome (CFS; n = 49) and a matched healthy control (HC) group (n = 20). Sleep initiation and sleep...

...Benjamin Fischler; Hugo D’Haenen; Raymond Cluydts; Veronique Michiels; Kathy Demets; Axel Bossuyt; Leonard Kaufman; Kenny De Meirleir An explorative analysis of the relationship between symptomatology and cerebral blood flow in the chronic fatigue syndrome (CFS) as assessed with 99m Tc HMPAO SPECT...

...A.V. Plioplys; S. Plioplys Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in chronic fatigue syndrome (CFS) patients. One previous investigation has reported decreased acylcarnitine levels in 38 CFS...

...Daniel Neu; Olivier Mairesse; Guy Hoffmann; Amirouche Dris; Luc J. Lambrecht; Paul Linkowski; Paul Verbanck; Olivier Le Bon Background/Aims: One of the core symptoms of the chronic fatigue syndrome (CFS) is unrefreshing sleep and a subjective sensation of poor sleep quality. Whether this perception...

...John E. Ottenweller; Sue A. Sisto; Richard C. McCarty; Benjamin H. Natelson Chronic fatigue syndrome (CFS) is a debilitating disease characterized by severe, unexplained fatigue and postexertional exacerbation of symptoms. We examined basal endocrine function in a group of CFS patients...

...S.M. MacHale; J.T.O. Cavanagh; J. Bennie; S. Carroll; G.M. Goodwin; S.M. Lawrie Baseline morning and evening serum cortisol and ACTH concentrations, and diurnal changes in hormone levels, were measured in 30 patients with chronic fatigue syndrome (CFS) but without concurrent depressive disorder...

... with depression and somatization, i.e., chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity, and Persian Gulf syndrome. These syndromes can involve many somatic symptoms consistent with possible inflammation. Immunological or neurogenic triggering might account for such inflammation. Serum...

...Benjamin H. Natelson; Joseph Cheu; Nancy Hill; Michael Bergen; Leo Korn; Thomas Denny; Kristina Dahl Aim: To perform a clinical trial of selegiline in 25 patients with chronic fatigue syndrome (CFS) where patients were told they would receive placebo or active agent at different times during the 6...

...Barbara Wood; Simon Wessely; Andrew Papadopoulos; Lucia Poon; Stuart Checkley Salivary cortisol profiles (hourly sampling over a 16-hour period) of 10 patients with chronic fatigue syndrome (CFS) but without concurrent depressive disorder were compared with those of 10 healthy volunteers matched...