...Evelyn Kiive; Triin Kurrikoff; Toomas Veidebaum; Jaanus Harro Introduction: The role of catechol-O-methyltransferase (COMT) in catecholamine neurotransmitter metabolism has led to the investigation of variants of the corresponding gene in the etiology of different psychiatric disorders...

...Mi Su; Yongyan Song Background: Genetic factors were suggested to have influence on the development of post-traumatic stress disorder (PTSD). The possible association between catechol-O-methyltransferase ( COMT ) Val158Met polymorphism and PTSD has been evaluated in several studies. But the results...

... of temperament and character, identifying catechol-O-methyltransferase (COMT), brain derived neurotrophic factor (BDNF), and serotonin transporter (5-HTT) gene variants as strong candidates. Methods: In the GECO-BIP study, 125 BD patients and 173 HC were recruited. Subjects underwent to a detailed assessment...

... of evidence suggest that genetic factors might influence an individual's vulnerability to panic disorder, gene-gender interactions are being examined in such psychiatric disorders and mental traits. A number of studies have suggested that specific genes, e.g. catechol-O-methyltransferase (COMT), might lead...

... polymorphism, the Val158Met catechol- O -methyltransferase (COMT) polymorphism, and the variable number of tandem repeat polymorphism of monoamine oxidase A (MAOA) on cognitive performance parameters within a group of 200 healthy women (age: mean ± SD, 23.93 ± 3.33 years). Results: The AP-2β polymorphism...

...Hwa-Young Lee; Yong-Ku Kim Genetic factors and catecholaminergic dysfunction have been suggested as the etiology of suicide. The catechol- O -methyltransferase (COMT) 158Val/Met polymorphism affects COMT activity; that is, the alleles encoding Val and Met are associated with relatively high...

...) and catechol-O-methyltransferase (COMT) genes have been implicated in neuroticism-related traits and approach-related temperaments which are supposed to be associated with disgust sensitivity. The present study aimed to investigate the possible relationship between disgust sensitivity and COMT Val158Met...

...Morton Levitt; Chyren Hunter; Miron Baron This report describes a simple and sensitive radiometric assay for catechol- o -methyltransferase activity in human erythrocytes and other tissues. Saturating concentrations of the endogenous catecholamines and S-adenosylmethionine are used under optimum...

...Ruth Feine; Robert H. Belmaker; Ranan Rimon; Richard P. Ebstein Platelet monoamine oxidase (MAO) and RBC catechol-O-methyltransferase (COMT) were studied in 12 women suffering from premenstrual syndrome. No significant variation of platelet MAO or RBC COMT was found during the menstrual cycle...

...Elżbieta Mikołajczyk; Małgorzata Śmiarowska; Anna Grzywacz; Jerzy Samochowiec Aim: The aim of this study was to evaluate functional catechol- O -methyltransferase (COMT) genetic variation as a risk factor for eating disorders (ED). Method: Eighty women receiving treatment for serious ED (52...

... in schizophrenia and have been associated with genetic liability. In a multicenter study involving 106 subjects, 56 with deficit schizophrenia and 50 with nondeficit schizophrenia, we tested the hypothesis that the catechol-O-methyltransferase (COMT) Val 158 Met polymorphism is associated with cognitive and motor...

...Shih-Jen Tsai; Chen-Jee Hong; Younger W.-Y. Yu; Tai-Jui Chen Human personality traits, which are substantially heritable, may be modulated by monoamine neurotransmitters. It has been demonstrated that the catechol-O-methyltransferase (COMT) Val158Met genetic polymorphism, a functional polymorphism...

...Shih-Jen Tsai; Chen-Jee Hong; Ding-Lieh Liao; I-Ching Lai; Ying-Jay Liou The gene coding for catechol- O -methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. This study aimed to assess the relationship...

...Ying-Jay Liou; Shih-Jen Tsai; Chen-Jee Hong; Ying-Chieh Wang; I-Ching Lai The catechol-O-methyltransferase (COMT) gene was thought to be a candidate gene for schizophrenia because of its role in inactivating dopamine. This study examined the relationship between a functional polymorphism (val158met...