... the therapeutic efficacy of antidepressants. In this study, we evaluated effective connectivity using isolated effective coherence (iCoh), an effective functional connectivity analysis method developed from low-resolution brain electromagnetic tomography (LORETA) and estimated its practical usefulness...

..., instructions or products referred to in the content or advertisements. Insulin-like growth factor-1 Antidepressants Depression Growth hormone Neurobiology Obsessive-compulsive disorder Serotonin reuptake inhibitors Treatment response Somatotropic axis Neurotrophic factors Insulin-like...

... of cognitive impairment for therapeutic outcome, and (2) to assess the association between cognitive performance and sBDNF levels over a 6-week course of antidepressant treatment. Methods: Twenty-five adult patients suffering from major depression underwent standardized treatment with duloxetine. Both severity...

...Bárbara Arias; Chiara Fabbri; Florence Gressier; Alessandro Serretti; Marina Mitjans; Cristóbal Gastó; Rosa Catalán; Diana De Ronchi; Lourdes Fañanás Background: Serotonergic genes have been widely investigated regarding antidepressant response in major depressive disorder (MDD) but results...

... in the pathophysiology of affective disorders and in the action of antidepressants. We analyzed the time course of 5-HT2C receptor (5-HTR2C) mRNA expression during antidepressant treatment in the prefrontal/frontal cortex (P/FC) and in the hippocampus (HC) of rats chronically treated with fluoxetine (a selective...

...Patrick Menu; Florence Gressier; Céline Verstuyft; Patrick Hardy; Laurent Becquemont; Emmanuelle Corruble Introduction: Pharmacogenetic factors may explain some of the interindividual variability of response to antidepressants in depressed patients. We focused on P-glycoprotein (P-GP), whose...

... from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar...

...Michael Bauer; Mazda Adli; Tom Bschor; Maximilian Pilhatsch; Andrea Pfennig; Johanna Sasse; Rita Schmid; Ute Lewitzka Background: The late onset of therapeutic response and a relatively large proportion of nonresponders to antidepressants remain major concerns in clinical practice. Therefore...

... in major depression. Seven polymorphisms in the promoter, intronic and exonic region of the NET gene, as well as serotonin-transporter-linked promoter region (5-HTTLPR) and 5-HTT rs25531 polymorphisms were analyzed with respect to antidepressant treatment response with particular attention to gender...

... concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action. 27 2 2008 © 1991 S. Karger AG, Basel 1990 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

...Hans-Peter Volz; Yvonne Sturm Nearly all antidepressants are tested psychometrically in order to detect side effects of these drugs. Based on a review of the relevant published data on critical flicker fusion frequency measurements, simple reaction time, complex reaction time, tracking, tapping...

... trial of antidepressant medication. Slope of P2 amplitude as a function of stimulus intensity was calculated for each subject and condition. Subjects were divided into two groups (responders and nonresponders) based on their Hamilton Rating Scale for depression scores following treatment. Responders had...

... in plasma free 3, 4-dihydroxyphenylglycol reached after 2–4 h. Such a pharmaco-EEG profile, occurring at doses inducing MAO-A inhibition, is similar to those already described with nonsedative antidepressants. Neuropsychobiology Pharmacoelectroencephalography Main Editor: W.M. Herrmann (Berlin) Original...

...) non-mood-disordered patients (n = 47), there were no differences in Mg 2+ levels or Ca 2+ /Mg 2+ ratios. Neither of these measures differed when comparing responders and nonresponders to antidepressant treatment. Magnesium Major depressive disorder Antidepressants Calcium © 1996 S. Karger...

... measurements. In addition to the improvement of mood, the tianeptine-treated patients presented less somatic complaints and side effects when compared to the reference antidepressant. These results confirm previous findings that tianeptine is an effective antidepressant with a lower side effect profile than...

...Takayuki Yamaji; Ariyuki Kagaya; Yasumasa Okamoto; Teruo Hayashi; Nobutaka Motohashi; Shigeto Yamawaki The effects of antidepressants and calcium (Ca 2+ ) antagonists on serotonin (5-HT)-induced Ca 2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy...

...-profiles by discriminant analysis, is presented. For the antidepressant drug class the success rate of correct classification of antidepressant drugs is between 53 and 88%, for a neuroleptic drug in the neuroleptic drug class the success rate is 87%, for an anxiolytic drug in the anxiolytic drug class 100...

...-effect profile of a compound was based on normalization of data and on calculation of the first two factor values in comparison with pooled data of representatives of neuroleptic, anxiolytic, convulsant, petit mal anticonvulsant, antidepressant and psychostimulant drug classes. The compounds were...

.... Antidepressants Clomipramine Sleep deprivation Septal nuclei 22 2 2008 Biological Psychiatry Original Paper Neuropsychobiology 1993;27:83-85 Carlos M. Contreras Ma. Luisa Adarvan Veronica Alcalá-Herrera Laboratorio de Neurofarmacoiogía. Departamento de Fisiología. Instituto de Investigaciones...

... long-lasting changes in neuronal activity. 22 2 2008 Antidepressants Electroconvulsive shock Septal nuclei © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...