... examine these properties of CBD using the ‘depressive-like' Wistar-Kyoto (WKY) rat, focusing on the drug's effect on anhedonia-like behaviors. Methods: Forty-eight WKY and 48 control Wistar adult male rats were pretreated orally with CBD (15, 30 and 45 mg/kg) or vehicle. The saccharin preference test (SPT...

... than others. Carriers of the S or L G allele of the 5-HTTLPR/rs25531 polymorphisms (S’ participants) have been found to be more prone to developing depression under stress relative to L or L A homozygotes (L’ participants). Moreover, emerging evidence indicates that stress-induced anhedonia may...

... biochemistry after habituation to CVS that might be implicated in successful adaptation to chronic stress. Chronic variable stress Anhedonia Exploration Cytochrome oxidase histochemistry Dopamine D 1 receptor Individual differences 4 10 2010 23 01 2011 21 6 2011 © 2011 S...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chronic mild stress Animal model of depression Antidepressants Anhedonia Dopamine agonists Review Neuropsychobiology 2005;52:90 110 DOI...

...L. Janiri; G. Martinotti; T. Dario; D. Reina; F. Paparello; G. Pozzi; G. Addolorato; M. Di Giannantonio; S. De Risio Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, frequently occurring in mood disorders, as a negative symptom in schizophrenia...