...Harikesh Dubey; Arunabha Ray; Anamika Dubey; Kavita Gulati Introduction: The brain-derived neurotrophic factor (BDNF) and transcription nuclear factor erythroid 2-related factor-2 (NRF-2) play an important role in Alzheimer’s disease (AD). However, the interactive involvement of BDNF and NRF-2...

... (HVs, N = 55), patients with Alzheimer’s disease (AD, N = 101), dementia with Lewy bodies (DLB, N = 75), and idiopathic normal pressure hydrocephalus (iNPH, N = 60) to evaluate the discriminative accuracy of these diseases. Results: High discriminative accuracies were archived between HV and patients...

...Mohammadali Amini; Zohreh Abdolmaleki Introduction: Using nanoparticle (NP) drugs can have better effects on the target tissue in various diseases. Alzheimer’s disease (AD) is one of the degenerative neurological diseases that due to its high prevalence, requires the use of more appropriate...

...Stefano Porcelli; Marco Calabrò; Concetta Crisafulli; Antonis Politis; Ioannis Liappas; Diego Albani; Ilaria Raimondi; Gianluigi Forloni; Francesco Benedetti; George N. Papadimitriou; Alessandro Serretti Background: Alzheimer’s disease (AD) is a neurodegenerative disorder accounting for 60–70...

...Mir Hilal Ahmad; Mahino Fatima; Amal Chandra Mondal Alzheimer’s disease (AD), the commonest progressive neurodegenerative disorder of the brain, is clinically characterized by the formation of extracellular amyloid plaques and intracellular neurofibrillary tangles. Recent studies suggest...

... neuropsychological battery including the SCWT was administered to 237 cognitively normal controls (NC), 221 patients with mild cognitive impairment (MCI), and 160 patients with Alzheimer’s disease (AD). We compared the accuracy for different items of card C (SCWT-C10 accuracy , SCWT-C24 accuracy , and SCWT-C50...

...Qi-He Dai; Dao-Kai Gong Objective: To investigate whether the polymorphisms and plasma level of chitinase-3-like protein 1 (CHI3L1) are associated with Alzheimer’s disease (AD) in the Chinese Han population. Methods: A total of 166 patients who were initially diagnosed with AD were enrolled...

...Vincenzo De Luca; Gianfranco Spalletta; Renan P. Souza; Ariel Graff; Luciana Bastos-Rodrigues; Maria Aparecida Camargos Bicalho Background/Objectives: This study aims to investigate the role of apolipoprotein E (APOE) e4 influencing the age at onset (AAO) of Alzheimer’s disease (AD). In AD, the AAO...

...Dominik Kwiatkowski; Piotr Czarny; Monika Toma; Anna Korycinska; Katarzyna Sowinska; Piotr Galecki; Agnieszka Bachurska; Anna Bielecka-Kowalska; Janusz Szemraj; Michael Maes; Tomasz Sliwinski Background: One of the factors that contribute to Alzheimer's disease (AD) is the DNA damage caused...

...Fei Ma; Jianhua Wang; Rujuan Miao; Wei Zhao; Qian Wang Background/Aims: Cognitive decline in the elderly is an early predictor of dementia. The apolipoprotein E (APOE) Ε4 allele is considered an important genetic determinant of Alzheimer’s disease (AD), and strongly suspected to play a role...

... will be decreased in Alzheimer’s disease (AD) since neurochemical studies suggest that levels of 5-HT are decreased in the brain of AD patients. We investigated platelet and plasma 5-HT in a group of AD patients (n = 22) as well as in age-matched normal control subjects (n = 20). The results show that the platelet...

... Alzheimer’s disease Alcoholism Aggressiveness Biological Psychiatry Original Paper Ncuropsychobiology 1994:30:73-78 George Kirilov Kirov Nicholas John Birch Philip Steadman Robert Greig Ramsey Warlingham Park Hospital, Warlingham. and Biomedical Research Laboratory, School o f Health Sciences, University...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Segmentation Microstate Dementia Alzheimer’s disease Electroencephalography EEG Pharmacoelectroencephalography Original Paper Neuropsychobiology 1993:27:231-236 R...

... Disease Key Words ß-Endorphin Cortisol Alzheimer's Disease Multi-infarct dementia Elderly Abstract A chronobiological study was carried out in 6 male patients (67-71 years), suffering from Alzheimer-type dementia (ATD) and 6 male patients (52-74 years) suffering from multi-infarct dementia (MID...

...Wade H. Berrettini; Walter H. Kaye; Trey Sunderland; Conrad May; Harry E. Gwirtsman; Alan Mellow; Allen Albright Galanin is a peptide which stimulates feeding behavior in animals and is found within those basal forebrain cholinergic neurons which degenerate in Alzheimer’s disease. Galanin...

... in the platelets. [ 3 H]-Imipramine Serotonin Alzheimer’s disease Platelets © 1988 S. Karger AG, Basel 1988 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means...

...Mervyn Whitford Data from post-mortem brain, cerebrospinal fluid and serotonin (5-HT) synapse studies indicate serious impairment of the serotoninergic system in patients with Alzheimer’s disease. Decreased levels of the 5-HT metabolite 5-hydroxyindoleacetic acid have also been linked...

... why it is possible for some mnemonic elements to survive during aphasia and senile dementias, while closely linked synonymous engrams are lost. Memory molecules Overlapping memory codes Brain nucleic acids Senile dementias Alzheimer’s disease 19 2 2008 © 1986 S. Karger AG, Basel...

...Xiao-ming He; Zhen-xin Zhang; Jun-wu Zhang; Yong-tao Zhou; Mou-ni Tang; Cheng-bin Wu; Zhen Hong Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by excessive neuronal loss in specific regions of the brain. Among the areas most severely affected are the basal...

...N. Tsuno; M. Shigeta; K. Hyoki; P.L. Faber; D. Lehmann Vascular dementia (VaD) differs from Alzheimer’s disease (AD) in larger fluctuations of cognitive impairment, hypothetically because of deteriorated vigilance control. Vigilance levels are reflected by locations of EEG sources. Transition from...