...Sharon Pellow; Sandra E. File The β-carboline FG 7142 and pentylenetetrazole, believed to act at different sites on the GABA-benzodiazepine receptor complex, have anxiogenic activity in the social interaction test in the rat. Two compounds that have anti-panic activity in man, the tricyclic...

... at different sites in the central nervous system: yohimbine, by blocking the α2-adrenoceptor; FG 7142, by action at the β-carboline site on the GABA-benzodiazepine receptor complex and pentylenetetrazole, by acting at the picrotoxinin site on this complex. Administration of imipramine following 21 days pre...