Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

2.

Choby

B

.

Diabetes Update: Prevention and Management of Diabetes Complications

.

FP Essent

.

2017

May

;

456

:

36

–

40

.

[PubMed]

2159-3000

https://doi.org/10.4239/wjd.v7.i2.14

3.

Drewes

AM

,

Søfteland

E

,

Dimcevski

G

,

Farmer

AD

,

Brock

C

,

Frøkjær

JB

, et al.

Brain changes in diabetes mellitus patients with gastrointestinal symptoms

.

World J Diabetes

.

2016

Jan

;

7

(

2

):

14

–

26

.

[PubMed]

1948-9358

4.

Mustafa

SB

,

Mehmood

Z

,

Akhter

N

,

Kauser

A

,

Hussain

I

,

Rashid

A

, et al.

Review-Medicinal plants and management of Diabetes Mellitus: A review

.

Pak J Pharm Sci

.

2016

Sep

;

29

(

5

Suppl

):

1885

–

91

.

[PubMed]

1011-601X

https://doi.org/10.1007/s11892-016-0775-x

5.

Zilliox

LA

,

Chadrasekaran

K

,

Kwan

JY

,

Russell

JW

.

Diabetes and Cognitive Impairment

.

Curr Diab Rep

.

2016

Sep

;

16

(

9

):

87

.

[PubMed]

1534-4827

https://doi.org/10.1016/j.nlm.2010.01.004

6.

Hasanein

P

,

Shahidi

S

.

Effects of combined treatment with vitamins C and E on passive avoidance learning and memory in diabetic rats

.

Neurobiol Learn Mem

.

2010

May

;

93

(

4

):

472

–

8

.

[PubMed]

1074-7427

https://doi.org/10.1002/ptr.3298

7.

Hasanein

P

,

Shahidi

S

.

Effects of Hypericum perforatum extract on diabetes-induced learning and memory impairment in rats

.

Phytother Res

.

2011

Apr

;

25

(

4

):

544

–

9

.

[PubMed]

0951-418X

https://doi.org/10.12659/MSM.882201

8.

Hasanein

P

,

Shahidi

S

.

Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats

.

Med Sci Monit

.

2012

Jan

;

18

(

1

):

BR41

–

6

.

[PubMed]

1234-1010

https://doi.org/10.1016/j.brainresbull.2013.12.013

9.

Jabbarpour

Z

,

Shahidi

S

,

Saidijam

M

,

Sarihi

A

,

Hassanzadeh

T

,

Esmaeili

R

.

Effect of tempol on the passive avoidance and novel object recognition task in diabetic rats

.

Brain Res Bull

.

2014

Feb

;

101

:

51

–

6

.

[PubMed]

0361-9230

https://doi.org/10.1016/j.pcd.2007.10.002

10.

Talley

M

,

Pryor

E

,

Wadley

V

,

Crowe

M

,

Morrison

S

,

Vance

D

: The Physiological Mechanisms of Diabetes and Aging on Brain Health and Cognition: Implications for Nursing Practice and Research. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

2015

;47:E12-22.

11.

Biessels

GJ

,

Kerssen

A

,

de Haan

EH

,

Kappelle

LJ

.

Cognitive dysfunction and diabetes: implications for primary care

.

Prim Care Diabetes

.

2007

Dec

;

1

(

4

):

187

–

93

.

[PubMed]

1751-9918

https://doi.org/10.1530/EJE-08-0024

12.

van Deutekom

AW

,

Niessen

HW

,

Schalkwijk

CG

,

Heine

RJ

,

Simsek

S

.

Increased Nepsilon-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus

.

Eur J Endocrinol

.

2008

May

;

158

(

5

):

655

–

60

.

[PubMed]

0804-4643

https://doi.org/10.1080/00207450600934531

13.

Kucukatay

V

,

Ağar

A

,

Gumuslu

S

,

Yargiçoğlu

P

.

Effect of sulfur dioxide on active and passive avoidance in experimental diabetes mellitus: relation to oxidant stress and antioxidant enzymes

.

Int J Neurosci

.

2007

Aug

;

117

(

8

):

1091

–

107

.

[PubMed]

0020-7454

https://doi.org/10.1111/j.1749-6632.2001.tb05646.x

14.

Fukui

K

,

Onodera

K

,

Shinkai

T

,

Suzuki

S

,

Urano

S

.

Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems

.

Ann N Y Acad Sci

.

2001

Apr

;

928

(

1

):

168

–

75

.

[PubMed]

0077-8923

https://doi.org/10.1016/S0006-8993(02)02887-1

15.

Li

ZG

,

Zhang

W

,

Grunberger

G

,

Sima

AA

.

Hippocampal neuronal apoptosis in type 1 diabetes

.

Brain Res

.

2002

Aug

;

946

(

2

):

221

–

31

.

[PubMed]

0006-8993

https://doi.org/10.1016/j.bbr.2011.01.022

16.

Bhutada

P

,

Mundhada

Y

,

Bansod

K

,

Tawari

S

,

Patil

S

,

Dixit

P

, et al.

Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes

.

Behav Brain Res

.

2011

Jun

;

220

(

1

):

30

–

41

.

[PubMed]

0166-4328

https://doi.org/10.1016/j.expneurol.2005.07.012

17.

Moreira

PI

,

Santos

MS

,

Sena

C

,

Nunes

E

,

Seiça

R

,

Oliveira

CR

.

CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats

.

Exp Neurol

.

2005

Nov

;

196

(

1

):

112

–

9

.

[PubMed]

0014-4886

https://doi.org/10.1159/000360101

18.

Garrido-Maraver

J

,

Cordero

MD

,

Oropesa-Ávila

M

,

Fernández Vega

A

,

de la Mata

M

,

Delgado Pavón

A

, et al.

Coenzyme q10 therapy

.

Mol Syndromol

.

2014

Jul

;

5

(

3-4

):

187

–

97

.

[PubMed]

1661-8769

https://doi.org/10.1002/nau.20662

19.

Juan

YS

,

Chuang

SM

,

Mannikarottu

A

,

Huang

CH

,

Li

S

,

Schuler

C

, et al.

Coenzyme Q10 diminishes ischemia-reperfusion induced apoptosis and nerve injury in rabbit urinary bladder

.

Neurourol Urodyn

.

2009

;

28

(

4

):

339

–

42

.

[PubMed]

0733-2467

https://doi.org/10.5620/eht.2014.29.e2014001

20.

Majumdar

A

,

Nirwane

A

,

Kamble

R

.

New evidences of neurotoxicity of aroclor 1254 in mice brain: potential of coenzyme q10 in abating the detrimental outcomes

.

Environ Health Toxicol

.

2014

Mar

;

29

:

e2014001

.

[PubMed]

2233-6567

https://doi.org/10.2174/1568026615666150827095252

21.

Yang

X

,

Zhang

Y

,

Xu

H

,

Luo

X

,

Yu

J

,

Liu

J

, et al.

Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases

.

Curr Top Med Chem

.

2016

;

16

(

8

):

858

–

66

.

[PubMed]

1568-0266

https://doi.org/10.1007/s11897-016-0296-6

22.

Oleck

S

,

Ventura

HO

.

Coenzyme Q10 and Utility in Heart Failure: Just Another Supplement?

Curr Heart Fail Rep

.

2016

Aug

;

13

(

4

):

190

–

5

.

[PubMed]

1546-9530

https://doi.org/10.1007/s10517-012-1529-7

23.

Dzugkoev

SG

,

Kaloeva

MB

,

Dzugkoeva

FS

.

Effect of combination therapy with coenzyme Q10 on functional and metabolic parameters in patients with type 1 diabetes mellitus

.

Bull Exp Biol Med

.

2012

Jan

;

152

(

3

):

364

–

6

.

[PubMed]

0007-4888

https://doi.org/10.1016/j.ejphar.2007.03.006

24.

Tsuneki

H

,

Sekizaki

N

,

Suzuki

T

,

Kobayashi

S

,

Wada

T

,

Okamoto

T

, et al.

Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells

.

Eur J Pharmacol

.

2007

Jul

;

566

(

1-3

):

1

–

10

.

[PubMed]

0014-2999

25.

Moradi

M

,

Haghighatdoost

F

,

Feizi

A

,

Larijani

B

,

Azadbakht

L

.

Effect of Coenzyme Q10 Supplementation on Diabetes Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials

.

Arch Iran Med

.

2016

Aug

;

19

(

8

):

588

–

96

.

[PubMed]

1735-3947

https://doi.org/10.1016/j.abb.2015.11.026

26.

Yamamoto

Y

.

Coenzyme Q10 redox balance and a free radical scavenger drug

.

Arch Biochem Biophys

.

2016

Apr

;

595

:

132

–

5

.

[PubMed]

0003-9861

https://doi.org/10.1089/ars.2007.9.233

27.

Kishida

KT

,

Klann

E

:

Sources and targets of reactive oxygen species in synaptic plasticity and memory.

Antioxidants & redox signaling

2007

;9:233-244.

https://doi.org/10.1016/j.pbb.2015.02.005

28.

Barzegar

S

,

Komaki

A

,

Shahidi

S

,

Sarihi

A

,

Mirazi

N

,

Salehi

I

.

Effects of cannabinoid and glutamate receptor antagonists and their interactions on learning and memory in male rats

.

Pharmacol Biochem Behav

.

2015

Apr

;

131

:

87

–

90

.

[PubMed]

0091-3057

https://doi.org/10.1155/2014/798535

29.

Ghahremanitamadon

F

,

Shahidi

S

,

Zargooshnia

S

,

Nikkhah

A

,

Ranjbar

A

,

Soleimani Asl

S

.

Protective effects of Borago officinalis extract on amyloid β-peptide(25-35)-induced memory impairment in male rats: a behavioral study

.

BioMed Res Int

.

2014

;

2014

:

798535

.

[PubMed]

2314-6133

https://doi.org/10.1016/j.physbeh.2015.03.015

30.

Khodamoradi

N

,

Komaki

A

,

Salehi

I

,

Shahidi

S

,

Sarihi

A

.

Effect of vitamin E on lead exposure-induced learning and memory impairment in rats

.

Physiol Behav

.

2015

May

;

144

:

90

–

4

.

[PubMed]

0031-9384

https://doi.org/10.1016/j.pbb.2015.02.008

31.

Komaki

A

,

Karimi

SA

,

Salehi

I

,

Sarihi

A

,

Shahidi

S

,

Zarei

M

.

The treatment combination of vitamins E and C and astaxanthin prevents high-fat diet induced memory deficits in rats

.

Pharmacol Biochem Behav

.

2015

Apr

;

131

:

98

–

103

.

[PubMed]

0091-3057

https://doi.org/10.1016/j.physbeh.2011.01.011

32.

Mahmoodi

M

,

Shahidi

S

,

Hasanein

P

.

Involvement of the ventral tegmental area in the inhibitory avoidance memory in rats

.

Physiol Behav

.

2011

Mar

;

102

(

5

):

542

–

7

.

[PubMed]

0031-9384

https://doi.org/10.1016/j.brainres.2008.02.008

33.

Shahidi

S

,

Komaki

A

,

Mahmoodi

M

,

Lashgari

R

.

The role of GABAergic transmission in the dentate gyrus on acquisition, consolidation and retrieval of an inhibitory avoidance learning and memory task in the rat

.

Brain Res

.

2008

Apr

;

1204

:

87

–

93

.

[PubMed]

0006-8993

https://doi.org/10.3233/JAD-2011-110209

34.

Dumont

M

,

Kipiani

K

,

Yu

F

,

Wille

E

,

Katz

M

,

Calingasan

NY

, et al.

Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer’s disease

.

J Alzheimers Dis

.

2011

;

27

(

1

):

211

–

23

.

[PubMed]

1387-2877

https://doi.org/10.1186/1471-2202-10-88

35.

Somayajulu-Niţu

M

,

Sandhu

JK

,

Cohen

J

,

Sikorska

M

,

Sridhar

TS

,

Matei

A

, et al.

Paraquat induces oxidative stress, neuronal loss in substantia nigra region and parkinsonism in adult rats: neuroprotection and amelioration of symptoms by water-soluble formulation of coenzyme Q10

.

BMC Neurosci

.

2009

Jul

;

10

(

1

):

88

.

[PubMed]

1471-2202

https://doi.org/10.3945/jn.109.110437

36.

Sumien

N

,

Heinrich

KR

,

Shetty

RA

,

Sohal

RS

,

Forster

MJ

.

Prolonged intake of coenzyme Q10 impairs cognitive functions in mice

.

J Nutr

.

2009

Oct

;

139

(

10

):

1926

–

32

.

[PubMed]

0022-3166

https://doi.org/10.1016/j.freeradbiomed.2004.11.014

37.

McDonald

SR

,

Sohal

RS

,

Forster

MJ

.

Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice

.

Free Radic Biol Med

.

2005

Mar

;

38

(

6

):

729

–

36

.

[PubMed]

0891-5849

https://doi.org/10.1155/2013/963520

38.

Popa-Wagner

A

,

Mitran

S

,

Sivanesan

S

,

Chang

E

,

Buga

AM

.

ROS and brain diseases: the good, the bad, and the ugly

.

Oxid Med Cell Longev

.

2013

;

2013

:

963520

.

[PubMed]

1942-0900

https://doi.org/10.1042/bst0290345

39.

Hancock

JT

,

Desikan

R

,

Neill

SJ

.

Role of reactive oxygen species in cell signalling pathways

.

Biochem Soc Trans

.

2001

May

;

29

(

Pt 2

):

345

–

50

.

[PubMed]

0300-5127

https://doi.org/10.1016/j.brainres.2015.10.007

40.

Salehi

I

,

Karamian

R

,

Komaki

A

,

Tahmasebi

L

,

Taheri

M

,

Nazari

M

, et al.

Effects of vitamin E on lead-induced impairments in hippocampal synaptic plasticity

.

Brain Res

.

2015

Dec

;

1629

:

270

–

81

.

[PubMed]

0006-8993

https://doi.org/10.1016/j.brainresbull.2015.05.004

41.

Karamian

R

,

Komaki

A

,

Salehi

I

,

Tahmasebi

L

,

Komaki

H

,

Shahidi

S

, et al.

Vitamin C reverses lead-induced deficits in hippocampal synaptic plasticity in rats

.

Brain Res Bull

.

2015

Jul

;

116

:

7

–

15

.

[PubMed]

0361-9230

https://doi.org/10.1007/s10339-011-0430-z

42.

Antunes

M

,

Biala

G

.

The novel object recognition memory: neurobiology, test procedure, and its modifications

.

Cogn Process

.

2012

May

;

13

(

2

):

93

–

110

.

[PubMed]

1612-4782

https://doi.org/10.1016/j.nlm.2014.12.014

43.

Giovannini

MG

,

Lana

D

,

Pepeu

G

.

The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory

.

Neurobiol Learn Mem

.

2015

Mar

;

119

:

18

–

33

.

[PubMed]

1074-7427

44.

Lin

LW

,

Tsai

FS

,

Yang

WT

,

Lai

SC

,

Shih

CC

,

Lee

SC

, et al.

Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetes rats

.

Iran J Basic Med Sci

.

2018

;

21

:

1026

–

34

.2008-3866

45.

Fang

H

,

Xu

XY

,

Xu

RZ

,

Zhen

YF

,

Xu

G

,

Li

YK

.

Decreased serum undercarboxylated osteocalcin is associated with cognitive impairment in male patients with type 2 diabetes

.

J Diabetes Complications

.

2017

.

[PubMed]

1056-8727

https://doi.org/10.3233/JAD-161250

46.

Li

W

,

Huang

E

,

Gao

S

.

Type 1 Diabetes Mellitus and Cognitive Impairments: A Systematic Review

.

J Alzheimers Dis

.

2017

;

57

(

1

):

29

–

36

.

[PubMed]

1387-2877

https://doi.org/10.1007/s11011-013-9467-2

47.

Piazza

FV

,

Segabinazi

E

,

Centenaro

LA

,

do Nascimento

PS

,

Achaval

M

,

Marcuzzo

S

.

Enriched environment induces beneficial effects on memory deficits and microglial activation in the hippocampus of type 1 diabetic rats

.

Metab Brain Dis

.

2014

Mar

;

29

(

1

):

93

–

104

.

[PubMed]

0885-7490

https://doi.org/10.1016/j.physbeh.2017.10.001

48.

Wang

H

,

Sun

X

,

Zhang

N

,

Ji

Z

,

Ma

Z

,

Fu

Q

, et al.

Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway

.

Physiol Behav

.

2017

Dec

;

182

:

93

–

100

.

[PubMed]

0031-9384

49.

Zarrinkalam

E

,

Ranjbar

K

,

Salehi

I

,

Kheiripour

N

,

Komaki

A

:

Resistance training and hawthorn extract ameliorate cognitive deficits in streptozotocin-induced diabetic rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2017

;97:503-510.

https://doi.org/10.1586/14789450.2015.1104251

50.

Ly

H

,

Despa

F

.

Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes

.

Expert Rev Proteomics

.

2015

;

12

(

6

):

575

–

7

.

[PubMed]

1478-9450

https://doi.org/10.1016/j.bbadis.2014.06.010

51.

Butterfield

DA

,

Di Domenico

F

,

Barone

E

.

Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain

.

Biochim Biophys Acta

.

2014

Sep

;

1842

(

9

):

1693

–

706

.

[PubMed]

0006-3002

https://doi.org/10.4103/2008-7802.178531

52.

Sadeghi

A

,

Hami

J

,

Razavi

S

,

Esfandiary

E

,

Hejazi

Z

.

The Effect of Diabetes Mellitus on Apoptosis in Hippocampus: Cellular and Molecular Aspects

.

Int J Prev Med

.

2016

Mar

;

7

(

1

):

57

.

[PubMed]

2008-7802

https://doi.org/10.1016/j.bbr.2006.03.009

53.

Ishrat

T

,

Khan

MB

,

Hoda

MN

,

Yousuf

S

,

Ahmad

M

,

Ansari

MA

, et al.

Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats

.

Behav Brain Res

.

2006

Jul

;

171

(

1

):

9

–

16

.

[PubMed]

0166-4328

https://doi.org/10.1016/j.ejphar.2004.02.052

54.

McCall

AL

.

Cerebral glucose metabolism in diabetes mellitus

.

Eur J Pharmacol

.

2004

Apr

;

490

(

1-3

):

147

–

58

.

[PubMed]

0014-2999

https://doi.org/10.1007/s11011-014-9546-z

55.

Sickmann

HM

,

Waagepetersen

HS

.

Effects of diabetes on brain metabolism—is brain glycogen a significant player?

Metab Brain Dis

.

2015

Feb

;

30

(

1

):

335

–

43

.

[PubMed]

0885-7490

https://doi.org/10.2337/dc08-1722

56.

Gonder-Frederick

LA

,

Zrebiec

JF

,

Bauchowitz

AU

,

Ritterband

LM

,

Magee

JC

,

Cox

DJ

, et al.

Cognitive function is disrupted by both hypo- and hyperglycemia in school-aged children with type 1 diabetes: a field study

.

Diabetes Care

.

2009

Jun

;

32

(

6

):

1001

–

6

.

[PubMed]

0149-5992

https://doi.org/10.3390/nu9050437

57.

Testa

R

,

Bonfigli

AR

,

Prattichizzo

F

,

La Sala

L

,

De Nigris

V

,

Ceriello

A

.

The “Metabolic Memory” Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications

.

Nutrients

.

2017

Apr

;

9

(

5

):

9

.

[PubMed]

2072-6643

https://doi.org/10.1016/j.bbr.2014.08.033

58.

Capiotti

KM

,

De Moraes

DA

,

Menezes

FP

,

Kist

LW

,

Bogo

MR

,

Da Silva

RS

.

Hyperglycemia induces memory impairment linked to increased acetylcholinesterase activity in zebrafish (Danio rerio)

.

Behav Brain Res

.

2014

Nov

;

274

:

319

–

25

.

[PubMed]

0166-4328

https://doi.org/10.1530/EDM-17-0101

59.

Price

TO

,

Farr

SA

,

Niehoff

ML

,

Ercal

N

,

Morley

JE

,

Shah

GN

: Protective Effect of Topiramate on Hyperglycemia-Induced Cerebral Oxidative Stress, Pericyte Loss and Learning Behavior in Diabetic Mice. International library of diabetes & metabolism

2015

;1:6-12.

60.

Cerasuolo

J

,

Izzo

A

:

Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes.

Endocrinology, diabetes & metabolism case reports

2017

;2017

https://doi.org/10.1016/j.neuint.2014.04.011

61.

Bhardwaj

M

,

Kumar

A

: Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition. Pharmacological reports : PR

2016

;68:1301-1311.

62.

Sandhir

R

,

Sethi

N

,

Aggarwal

A

,

Khera

A

.

Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause

.

Neurochem Int

.

2014

Jul

;

74

:

16

–

23

.

[PubMed]

0197-0186

https://doi.org/10.1007/s12640-011-9289-0

63.

Binukumar

BK

,

Gupta

N

,

Sunkaria

A

,

Kandimalla

R

,

Wani

WY

,

Sharma

DR

, et al.

Protective efficacy of coenzyme Q10 against DDVP-induced cognitive impairments and neurodegeneration in rats

.

Neurotox Res

.

2012

May

;

21

(

4

):

345

–

57

.

[PubMed]

1029-8428

https://doi.org/10.1016/j.yebeh.2011.09.018

64.

Tawfik

MK

:

Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress.

Epilepsy & behavior : E&B

2011

;22:671-677.

https://doi.org/10.1016/j.neulet.2011.06.054

65.

Martin

SB

,

Cenini

G

,

Barone

E

,

Dowling

AL

,

Mancuso

C

,

Butterfield

DA

, et al.

Coenzyme Q10 and cognition in atorvastatin treated dogs

.

Neurosci Lett

.

2011

Aug

;

501

(

2

):

92

–

5

.

[PubMed]

0304-3940

https://doi.org/10.1097/FJC.0000000000000320

66.

Belousova

M

,

Tokareva

OG

,

Gorodetskaya

E

,

Kalenikova

EI

,

Medvedev

OS

.

Intravenous Treatment With Coenzyme Q10 Improves Neurological Outcome and Reduces Infarct Volume After Transient Focal Brain Ischemia in Rats

.

J Cardiovasc Pharmacol

.

2016

Feb

;

67

(

2

):

103

–

9

.

[PubMed]

0160-2446

https://doi.org/10.1007/s10517-016-3387-1

67.

Belousova

MA

,

Tokareva

OG

,

Gorodetskaya

EA

,

Kalenikova

EI

,

Medvedev

OS

.

Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia

.

Bull Exp Biol Med

.

2016

Jun

;

161

(

2

):

245

–

7

.

[PubMed]

0007-4888

68.

Kalenikova

EI

,

Gorodetskaia

EA

,

Belousova

MA

,

Kharitonova

EV

,

Tokareva

OV

,

Artem’eva

MM

, et al.

[Intravenous injection of coenzyme Q10 increases its level in rat brain]

.

Eksp Klin Farmakol

.

2014

;

77

(

10

):

36

–

7

.

[PubMed]

0869-2092

https://doi.org/10.1007/s11356-018-2398-z

69.

Sharma

A

,

Kshetrimayum

C

,

Sadhu

HG

,

Kumar

S

:

Arsenic-induced oxidative stress, cholinesterase activity in the brain of Swiss albino mice, and its amelioration by antioxidants Vitamin E and Coenzyme Q10.

2018

https://doi.org/10.1016/S0361-9230(00)00406-8

70.

Ostrowski

RP

.

Effect of coenzyme Q(10) on biochemical and morphological changes in experimental ischemia in the rat brain

.

Brain Res Bull

.

2000

Nov

;

53

(

4

):

399

–

407

.

[PubMed]

0361-9230

https://doi.org/10.1186/1471-2202-12-75

71.

Kalayci

M

,

Unal

MM

,

Gul

S

,

Acikgoz

S

,

Kandemir

N

,

Hanci

V

, et al.

Effect of coenzyme Q10 on ischemia and neuronal damage in an experimental traumatic brain-injury model in rats

.

BMC Neurosci

.

2011

Jul

;

12

(

1

):

75

.

[PubMed]

1471-2202

https://doi.org/10.1007/s004010050720

72.

Grieb

P

,

Ryba

MS

,

Sawicki

J

,

Chrapusta

SJ

.

Oral coenzyme Q10 administration prevents the development of ischemic brain lesions in a rabbit model of symptomatic vasospasm

.

Acta Neuropathol

.

1997

Oct

;

94

(

4

):

363

–

8

.

[PubMed]

0001-6322

https://doi.org/10.1073/pnas.95.15.8892

73.

Matthews

RT

,

Yang

L

,

Browne

S

,

Baik

M

,

Beal

MF

.

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

.

Proc Natl Acad Sci USA

.

1998

Jul

;

95

(

15

):

8892

–

7

.

[PubMed]

0027-8424

https://doi.org/10.1097/FBP.0b013e3283654029

74.

Aboul-Fotouh

S

.

Chronic treatment with coenzyme Q10 reverses restraint stress-induced anhedonia and enhances brain mitochondrial respiratory chain and creatine kinase activities in rats

.

Behav Pharmacol

.

2013

Oct

;

24

(

7

):

552

–

60

.

[PubMed]

0955-8810

https://doi.org/10.3233/JAD-170275

75.

Muthukumaran

K

,

Kanwar

A

,

Vegh

C

,

Marginean

A

,

Elliott

A

,

Guilbeault

N

, et al.

Ubisol-Q10 (a Nanomicellar Water-Soluble Formulation of CoQ10) Treatment Inhibits Alzheimer-Type Behavioral and Pathological Symptoms in a Double Transgenic Mouse (TgAPEswe, PSEN1dE9) Model of Alzheimer’s Disease

.

J Alzheimers Dis

.

2018

;

61

(

1

):

221

–

36

.

[PubMed]

1387-2877

https://doi.org/10.1089/scd.2012.0604

76.

Choi

H

,

Park

HH

,

Lee

KY

,

Choi

NY

,

Yu

HJ

,

Lee

YJ

, et al.

Coenzyme Q10 restores amyloid beta-inhibited proliferation of neural stem cells by activating the PI3K pathway

.

Stem Cells Dev

.

2013

Aug

;

22

(

15

):

2112

–

20

.

[PubMed]

1547-3287

https://doi.org/10.1111/j.1532-5415.2010.03169.x

77.

Gao

S

,

Nguyen

JT

,

Hendrie

HC

,

Unverzagt

FW

,

Hake

A

,

Smith-Gamble

V

, et al.

Accelerated weight loss and incident dementia in an elderly African-American cohort

.

J Am Geriatr Soc

.

2011

Jan

;

59

(

1

):

18

–

25

.

[PubMed]

0002-8614

https://doi.org/10.1212/01.wnl.0000176061.33817.90

78.

Buchman

AS

,

Wilson

RS

,

Bienias

JL

,

Shah

RC

,

Evans

DA

,

Bennett

DA

.

Change in body mass index and risk of incident Alzheimer disease

.

Neurology

.

2005

Sep

;

65

(

6

):

892

–

7

.

[PubMed]

0028-3878

79.

Barrett-Connor

E

,

Edelstein

S

,

Corey-Bloom

J

,

Wiederholt

W

.

Weight loss precedes dementia in community-dwelling older adults

.

J Nutr Health Aging

.

1998

;

2

(

2

):

113

–

4

.

[PubMed]

1279-7707

https://doi.org/10.1371/journal.pone.0141641

80.

Alehagen

U

,

Aaseth

J

,

Johansson

P

.

Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens

.

PLoS One

.

2015

Dec

;

10

(

12

):

e0141641

.

[PubMed]

1932-6203

https://doi.org/10.1007/s00394-015-1042-7

81.

Raygan

F

,

Rezavandi

Z

,

Dadkhah Tehrani

S

,

Farrokhian

A

,

Asemi

Z

.

The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome

.

Eur J Nutr

.

2016

Dec

;

55

(

8

):

2357

–

64

.

[PubMed]

1436-6207

https://doi.org/10.1016/S0098-2997(97)00010-1

82.

Andersen

CB

,

Henriksen

JE

,

Hother-Nielsen

O

,

Vaag

A

,

Mortensen

SA

,

Beck-Nielsen

H

.

The effect of coenzyme Q10 on blood glucose and insulin requirement in patients with insulin dependent diabetes mellitus

.

Mol Aspects Med

.

1997

;

18

Suppl

:

S307

–

9

.

[PubMed]

0098-2997

83.

Hosseinzadeh-Attar

M

,

Kolahdouz Mohammadi

R

,

Eshraghian

M

,

Nakhjavani

M

,

Khorrami

E

,

Ebadi

M

, et al.

Reduction in asymmetric dimethylarginine plasma levels by coenzyme Q10 supplementation in patients with type 2 diabetes mellitus

.

Minerva Endocrinol

.

2015

Dec

;

40

(

4

):

259

–

66

.

[PubMed]

1827-1634

84.

Kolahdouz Mohammadi

R

,

Hosseinzadeh-Attar

MJ

,

Eshraghian

MR

,

Nakhjavani

M

,

Khorami

E

,

Esteghamati

A

.

The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients

.

Minerva Gastroenterol Dietol

.

2013

Jun

;

59

(

2

):

231

–

6

.

[PubMed]

1121-421X

https://doi.org/10.2337/dc08-1736

85.

Hamilton

SJ

,

Chew

GT

,

Watts

GF

.

Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients

.

Diabetes Care

.

2009

May

;

32

(

5

):

810

–

2

.

[PubMed]

0149-5992