Background: Recent studies have reported that polyunsaturated fatty acids (PUFAs) are associated with mood and behaviors including depression and suicide risk. The aim of this study was to examine the relationship between PUFAs and personality traits in healthy subjects. Methods: A total of 279 subjects completed the Temperament and Character Inventory and Beck Depression Inventory. Serum levels of the PUFAs eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), the ω-6 fatty acid arachidonic acid (AA), and dihomo-γ-linolenic acid were measured. Results: Pearson's correlation analysis showed a positive correlation between DHA and cooperativeness scores. In the multiple regression analysis, harm avoidance scores were positively associated with AA, and a negative association was found between the EPA/AA ratio and reward dependence scores. However, these associations were nonsignificant after a Bonferroni correction. Conclusion: The results of the present study suggest that the blood levels of PUFAs are not likely to be associated with personality traits.

1.
Das UN: Long-chain polyunsaturated fatty acids in memory formation and consolidation: further evidence and discussion. Nutrition 2003;19:988-994.
2.
De la Presa Owens S, Innis SM: Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. J Nutr 1999;129:2088-2093.
3.
Edwards R, Peet M, Shay J, Horrobin D: Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord 1998;48:149-156.
4.
Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY: Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res 1999;85:275-292.
5.
Mamalakis G, Tornaritis M, Kafatos A: Depression and adipose essential polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids 2002;67:311-318.
6.
De Vriese SR, Christophe AB, Maes M: Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: further evidence that lowered n-PUFAs are related to major depression. Life Sci 2003;73:3181-3187.
7.
Su KP, Huang SY, Chiu CC, Shen WW: Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13:267-272.
8.
Huan M, Hamazaki K, Sun Y, Itomura M, Liu H, Kang W, Watanabe S, Terasawa K, Hamazaki T: Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol Psychiatry 2004;56:490-496.
9.
Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE Jr, Marangell LB, Richardson AJ, Lake J, Stoll AL: Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 2006;67:1954-1968.
10.
Dinan T, Siggins L, Scully P, O'Brien S, Ross P, Stanton C: Investigating the inflammatory phenotype of major depression: focus on cytokines and polyunsaturated fatty acids. J Psychiatry Res 2009;43:471-476.
11.
Evans SJ, Prossin AR, Harrington GJ, Kamali M, Ellingrod VL, Burant CF, McInnis MG: Fats and factors: lipid profiles associate with personality factors and suicidal history in bipolar subjects. PLoS One 2012;7:e29297.
12.
Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer H: Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20:4 omega 6/C20:5 omega 4 ratio in cholesteryl esters and phospholipids. J Affect Disord 1996;38:35-46.
13.
Riemer S, Maes M, Christophe A, Rief W: Lowered omega-3 PUFAs are related to major depression, but not to somatization syndrome. J Affect Disord 2010;123:173-180.
14.
Adams PB, Lawson S, Sanigorski A, Sinclair AJ: Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996;31(suppl):S157-S161.
15.
Conklin SM, Manuck SB, Yao JK, Flory JD, Hibbeln JR, Muldoon MF: High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom Med 2007;69:932-934.
16.
Maes M, Mihaylova I, Leunis JC: In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett 2005;26:745-751.
17.
Ellis FR, Sanders TA: Long chain polyunsaturated fatty acids in endogenous depression. J Neurol Neurosurg Psychiatry 1977;40:168-169.
18.
Fehily AM, Bowey OA, Ellis FR, Meade BW, Dickerson JW: Plasma and erythrocyte membrane long chain polyunsaturated fatty acids in endogenous depression. Neurochem Int 1981;3:37-42.
19.
Tsai AC, Lucas M, Okereke OI, O'Reilly EJ, Mirzaei F, Kawachi I, Ascherio A, Willett WC: Suicide mortality in relation to dietary intake of n-3 and n-6 polyunsaturated fatty acids and fish: equivocal findings from 3 large US cohort studies. Am J Epidemiol 2014;179:1458-1466.
20.
Mamalakis G, Kiriakakis M, Tsibinos G, Hatzis C, Flouri S, Mantzoros C, Kafatos A: Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharmacol Biochem Behav 2006;85:474-479.
21.
Kotov R, Gamez W, Schmidt F, Watson D: Linking ‘big' personality traits to anxiety, depressive, and substance use disorders: a meta-analysis. Psychol Bull 2010;136;768-821.
22.
Marijnissen G, Tuinier S, Sijben AE, Verhoeven WM: The temperament and character inventory in major depression. J Affect Disord 2002;70:219-223.
23.
Smith DJ, Duffy L, Stewart ME, Muir WJ, Blackwood DH: High harm avoidance and low self-directedness in euthymic young adults with recurrent, early-onset depression. J Affect Disord 2005;87:83-89.
24.
Celikel FC, Kose S, Cumurcu BE, Erkorkmaz U, Sayar K, Borckardt JJ, Cloninger CR: Cloninger's temperament and character dimensions of personality in patients with major depressive disorder. Compr Psychiatry 2009;50:556-561.
25.
Khan AA, Jacobson KC, Gardner CO, Prescott CA, Kendler KS: Personality and comorbidity of common psychiatric disorders. Br J Psychiatry 2005;186:190-196.
26.
Kaneda A, Yasui-Furukori N, Nakagami T, Sato Y, Kaneko S: The influence of personality factors on paroxetine response time in patients with major depression. J Affect Disord 2011;135:321-325.
27.
Tanskanen A, Hibbeln JR, Hintikka J, Haatainen K, Honkalampi K, Viinamäki H: Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry 2001;58:512-513.
28.
Mamalakis G, Kalogeropoulos N, Andrikopoulos N, Hatzis C, Kromhout D, Moschandreas J, Kafatos A: Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete. Eur J Clin Nutr 2006;60:882-888.
29.
Hakkarainen R, Partonen T, Haukka J, Virtamo J, Albanes D, Lönnqvist J: Is low dietary intake of omega-3 fatty acids associated with depression? Am J Psychiatry 2004;161:567-569.
30.
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561-571.
31.
Cloninger CR, Svrakic DM, Przybeck TR: A psychobiological model of temperament and character. Arch Gen Psychiatry 1993;50:975-990.
32.
Cloninger CR, Przybeck TR, Svrakic DM, Wetzel RD: The Temperament and Character Inventory (TCI): A Guide to Its Development and Use. St Louis, Washington University, Center for Psychobiology of Personality, 1994.
33.
Kijima N, Saito R, Takeuchi M, Yoshino I, Ono Y, Kato M, Kitamura T: Cloninger's seven-factor model of temperament and character and Japanese version of Temperament and Character Inventory (TCI). Kikan Seishinka Shindangaku 1996;7:379-399.
34.
Conklin SM, Harris JI, Manuck SB, Yao JK, Hibbeln JR, Muldoon MF: Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. Psychiatry Res 2007;152:1-10.
35.
Yanagisawa N, Shimada K, Miyazaki T, Kume A, Kitamura Y, Ichikawa R, Ohmura H, Kiyanagi T, Hiki M, Fukao K, Sumiyoshi K, Hirose K, Matsumori R, Takizawa H, Fujii K, Mokuno H, Inoue N, Daida H: Polyunsaturated fatty acid levels of serum and red blood cells in apparently healthy Japanese subjects living in an urban area. J Atheroscler Thromb 2010;17:285-294.
36.
Simopoulos AP: The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence. J Nutr 2001;131(suppl):3065S-3073S.
37.
Chalon S, Vancassel S, Zimmer L, Guilloteau D, Durand G: Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission. Lipids 2001;36:937-944.
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