Objective: Migraineurs demonstrate abnormal information processing such as photic hypersensitivity. The photic driving response to photic stimulation (PS) is a reaction to the visual stimulation of electroencephalography (EEG). Both the photic driving response and photic hypersensitivity appear during light stimulation. We considered that evaluation of a migraineur's photic driving response may help to elucidate the mechanism of the migraineur's sensitive condition. Our study aimed to investigate EEG photic driving responses with a source-localizing method. Methods: We recorded spontaneous resting EEG with eyes closed from 20 electrodes on the scalp during the interictal phase. After recording, each PS was separately selected. We also analyzed EEG by fast Fourier transform and observed the spectrum frequency peaks and topographies in response to PS. Results: The photic driving response could be observed at a flashing rate of >15 Hz. Patients with photic hypersensitivity tended to show more photic driving regardless of the migraine subtype. Moreover, in topographies, their activated areas were shifted anteriorly from fundamental driving to harmonic driving for each photic frequency. This anterior shift was more evident with a longer duration of illness, although no significant differences were seen between migraine subtypes. The global field power value had a positive correlation with the duration of illness. Conclusion: Photic hypersensitivity and photic driving responses were increased in migraineurs. Photic hypersensitivity might result in sensitization of the limbic system.

1.
Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004;24(suppl 1):9-160.
2.
Golla FL, Winter AL: Analysis of cerebral responses to flicker in patients complaining of episodic headache. Electroencephalogr Clin Neurophysiol 1959;11:539-549.
3.
Lehmann D, Skrandies W: Reference-free identification of components of checkerboard evoked multichannel potentials fields. Electroencephalogr Clin Neurophysiol 1980;48:609-621.
4.
Pizzagalli D, Lehmann D, Koenig T, Regard M, Pascual-Marqui RD: Face-elicited ERPs and affective attitude: brain electric microstate and tomography analyses. Clin Neurophysiol 2000;111:521-531.
5.
Wackermann J, Lehmann D, Michel CM, Strik WK: Adaptive segmentation of spontaneous EEG map series into spatially defined microstates. Int J Psychophysiol 1993;14:269-283.
6.
Morillo LE, Alarcon F, Aranaga N, et al: Clinical characteristics and patterns of medication use of migraneurs in Latin America from 12 cities in 6 countries. Headache 2005;45:118-126.
7.
Kelman L, Tanis D: The relationship between migraine pain and other associated symptoms. Cephalalgia 2006;26:548-553.
8.
Adrian ED, Matthews BHC: The Berger rhythm: potential changes from the occipital lobes in man. Brain 1934;57:355-385.
9.
Takahashi T, Tsukahara Y, Kaneda S: Influence of pattern and red color on the photoconvulsive response and the photic driving. Tohoku J Exp Med 1981;133:129-137.
10.
Wada Y, Takizawa Y, Yamaguchi N: Abnormal photic driving responses in never-medicated schizophrenia patients. Schizophr Bull 1995;21:111-115.
11.
Drake ME Jr, Shy KE, Liss L: Quantitation of photic driving in dementia with normal EEG. Clin Electroencephalogr 1989;20:153-155.
12.
Kikuchi M, Wada Y, Koshino Y: Differences in EEG harmonic driving responses to photic stimulation between normal aging and Alzheimer's disease. Clin Electroencephalogr 2002;33:86-92.
13.
de Tommaso M, Sciruicchio V, Guido M, Sasanelli G, Specchio LM, Puca FM: EEG spectral analysis in migraine without aura attacks. Cephalalgia 1998;18:324-328.
14.
Schoenen J, Jamart B, Delwaide PJ: Electroencephalographic mapping in migraine during the critical and intercritical periods. Rev Electroencephalogr Neurophysiol Clin 1987;17:289-299.
15.
Noseda R, Kainz V, Jakubowski M, et al: A neural mechanism for exacerbation of headache by light. Nat Neurosci 2010;13:239-246.
16.
Bellebaum C, Daum I, Koch B, et al: The role of the human thalamus in processing corollary discharge. Brain 2005;128(pt 5):1139-1154.
17.
Dodick D, Silberstein S: Central sensitization theory of migraine: clinical implications. Headache 2006;46(suppl 4):S182-S191.
18.
Apkarian AV, Thomas PS, Krauss BR, et al: Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain. Neurosci Lett 2001;311:193-197.
19.
May A, Bahra A, Büchel C, et al: PET and MRA findings in cluster headache and MRA in experimental pain. Neurology 2000;55:1328-1335.
20.
Rome HP Jr, Rome JD: Limbically augmented pain syndrome (LAPS): kindling, corticolimbic sensitization, and the convergence of affective and sensory symptoms in chronic pain disorders. Pain Med 2000;1:7-23.
21.
Vanagaite J, Pareja JA, Støren O, et al: Light-induced discomfort and pain in migraine. Cephalalgia 1997;17:733-741.
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