Background: Genetic factors make a significant contribution to the determination of human personality traits. We aimed to investigate the possible relationship between dopamine receptor D2 (DRD2) Taq I A polymorphism and the reward-related personality traits as measured by the Carver and White Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and Cloninger’s Temperament and Character Inventory (TCI). Methods: The sample consisted of 267 female healthy Korean unrelated university students (age: 23.12 ± 3.22 years) and they filled out the BIS/BAS scales and the TCI. Genomic DNA was isolated from whole blood and genotyped with the fluorescence polarization detection method. The effect of the independent variables (DRD2 genotypes) on the dependent variables were analyzed by multivariate and subsequent univariate ANOVA. Results: We found significant associations between the A1 allele of the DRD2 Taq I A polymorphism and a high BAS-RR score (reward responsiveness). No significant association was observed between DRD2 polymorphisms and other factors of the BIS/BAS scales and TCI. Conclusion: These findings suggest the notion that DRD2 Taq I A polymorphism contributes to high reward sensitivity, which measures anticipation and positive response towards reward.

Keywords:
Dopamine receptor D2Taq I A polymorphism, Behavioral approach system, Personality traits
This content is only available via PDF.
© 2008 S. Karger AG, Basel
2008
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.