Plasma aldosterone, and serum and urine electrolytes were determined in 9 manic-depressive patients before and at several intervals during 3 months of lithium treatment. The same determinations were carried out in 27 manic-depressive patients who had been treated with lithium for 3 months to 20 years and also in a control group. There was no change in plasma aldosterone during the longitudinal study and no difference between patients and controls in the transversal study. The latter study revealed, however, a positive correlation between serum lithium and plasma aldosterone. Our study indicates that nontoxic lithium doses may produce slight sodium depletion in patients.

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