The sample investigated consisted of two groups of emotionally labile healthy male subjects who were given either 100 mg/day of the antiepileptic drug carbamazepine (n = 16) or placebo (n = 16) for 8 days. Subjects were selected on the basis of their scores in the neuroticism scale of the Freiburg Personality Inventory (FPI-A: N score S≥6). By means of an extensive test battery (ratings of emotional state, emotional reactivity tests, performance tests, physiological parameters) at day 1 and day 8 of ingestion the psychotropic effects of carbamazepine were evaluated as well as the differences in effects after single and repeated administration. Behavioral effects could be demonstrated for carbamazepine after single administration, but the differences found were rather small and limited to four parameters. After several days of administration carbamazepine revealed clear effects on psychological parameters. It is concluded that a drug like carbamazepine needs more than a single administration to be effective in psychological tests, in contrast to tranquilizing, sedating, neuroleptic and stimulating drugs. Carbamazepine has this characteristic common with antidepressant drugs. The experiment demonstrated that carbamazepine is a drug which under the chosen dose level conditions has a positive influence on subjective emotional states, e.g. reduction of deactivation and emotional tension (anxiousness).

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.