... nephropathy Glomerulonephritis Glomerulosclerosis CD80 Urokinase-type plasminogen activator receptor Podocyturia Proteinuria Integrins IgA nephropathy (IgAN) has been recognized as the most common form of primary glomerulonephritis and an important cause of chronic kidney disease and end-stage...

... phased, 12-month quality improvement (QI) projects with 49 primary care practices in GM. Two measureable aims were set – halve undiagnosed CKD in participating practices using modelled estimates of prevalence; and optimise blood pressure (BP) control (<140/90 mm Hg in CKD patients without proteinuria...

... and proteinuria of ≤0.33 g/day) and long-term outcomes (stable renal function, dialysis, and death) were compared. The patients were followed for 121 ± 64 months. Results: The baseline clinical features were similar, but the chronicity index was significantly higher with increasing levels of serum creatinine...

... involvement in PE [ 21 ], as injury leads to the loss of its interdigitation, a dedifferentiation process, and deficient adhesion to the glomerular basement membrane with consequent urinary podocyte excretion and development of glomerulosclerosis [ 22 ]. Proteinuria is probably the main cause...

... receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day –7 to day 9 of induction of podocyte injury. Results: Although MRB did not reduce systolic blood pressure or proteinuria, addition of MRB to ARB...

... biopsy were assessed in 10 and 9 patients, respectively. Proteinuria was significantly decreased by 56, 62 and 87% at 3, 6 and 12 months, respectively. At 6 months, 2 patients achieved complete remission (CR) and 12 partial remission (PR; overall renal response, 50%). At 12 months (n = 23), CR...

...Viknesh Selvarajah; Robert Flynn; Chris Isles Background: Current UK guidelines for the identification, management and referral of chronic kidney disease advise an early-morning urine sample for the albumin:creatinine ratio or the protein:creatinine ratio (PCR) in order to quantify proteinuria...

... < 0.01), and the serum IgA and AI had significantly decreased (88.1 ± 30.8 mg/dl, p < 0.05; 2.0 ± 1.2, p < 0.01, respectively), whereas the CI remained unchanged. Proteinuria disappeared within 24 months in all but 1 patient, and hematuria disappeared within 38 months in all patients. No patient...