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Keywords: Thymus
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Neuroimmunomodulation (2024) 31 (1): 78–88.
Published Online: 09 April 2024
... several neuropeptides, such as the neuropeptide Y, the vasoactive intestinal polypeptide, the substance P, the calcitonin gene-related peptide, has been described in human and animal thymuses [ 43‒46 ], but nowadays there is not enough evidence that these neuropeptides are associated with any sensory...
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Neuroimmunomodulation (2024) 31 (1): 51–61.
Published Online: 16 February 2024
... in different pathologies, mainly neurodevelopmental disorders and cancer. The expression levels of NRPs and SEMAs are also related to the progression of solid tumors. Besides the expression of class 3 SEMAs A and F, NRP1 and NRP2, and plexin A in the human thymuses in TECs and developing thymocytes...
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Neuroimmunomodulation (2024) 31 (1): 25–39.
Published Online: 21 December 2023
... equation: thymus/mouse weight (mg/g). For histological evaluation, thymuses were collected and fixed in a solution 2% paraformaldehyde for 12 h at room temperature. The specimens were submitted to diaphanization with xylene, dehydrated by graded ethanol series, embedded in paraffin, and cut into 5...
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Neuroimmunomodulation (2020) 27 (1): 28–37.
Published Online: 10 March 2020
... of thymocytes [ 7 ]. In addition, among cell migration-related interactions in the thymus, there are attractant as well as repulsive stimuli [ 8 ]. Fig. 1. Decrease in thymus cellularity in chemically induced diabetic mice. Compared to control animals, thymuses from diabetic mice presented alterations...
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Neuroimmunomodulation (2011) 18 (5): 281–289.
Published Online: 22 September 2011
... with a proportional increase in memory cells, and also a generally reduced function of these cells. While bone marrow function reduces with age, the most obvious reason for the T cell defects is the severe atrophy of the thymus. This is closely aligned with puberty, thereby implicating a major aetiological role...
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Neuroimmunomodulation (2011) 18 (5): 271–280.
Published Online: 22 September 2011
...] and cell proliferation of epithelial cells [70]. Thus, it is worth speculating that these molecules could mediate similar interactions between thymocytes and TEC in the thymus. In EphB-deficient thymuses, low numbers of TEC correlate with increased apoptosis and decreased proportion of dividing cells...
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Neuroimmunomodulation (2009) 16 (2): 96–105.
Published Online: 11 February 2009
.... Hypothalamus-pituitary-adrenal axis Intracellular pathogen infections Thymus Glucocorticoids Sex hormones Cytokines Extracellular matrix Thymic atrophy Neuroimmunomodulation 2009;16:96 105 DOI: 10.1159/000180264 Published online: February 11, 2009 The Impact of Infectious Diseases upon Neuroendocrine...
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Neuroimmunomodulation (2008) 15 (4-6): 290–322.
Published Online: 26 November 2008
... has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenaline in adult male and female thymus and (2) catecholamines, acting via α- and β-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both...
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Neuroimmunomodulation (2008) 15 (4-6): 351–364.
Published Online: 26 November 2008
... their thymuses. In humans, GH therapy was attempted in AIDS patients, since early research had already shown that AIDS promotes severe thymic atrophy [144]. As we mentioned before, thymopoiesis, as well as the numbers of in CD4+ T recent thymic emigrants, were increased in middle-aged AIDS patients that received...
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Neuroimmunomodulation (2008) 15 (1): 7–18.
Published Online: 29 July 2008
... thymuses, which lack pre-TCR signals and double-positive (DP) thymocytes. Together these studies indicate that estradiol treatment induced preferential depletion of early thymic progenitors [24]. Consistent with the loss of progenitors and subsequently reduced population of SP cells, morphometric analyses...
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Neuroimmunomodulation (2002) 10 (3): 177–186.
Published Online: 19 December 2002
... in the thymus, spleen and lymph nodes. Cytochemical results show that PACAP is present in thymocytes, lymphocytes and plasma cells from the spleen and lymph nodes. Western blot analysis showed a band corresponding to PACAP for all lymphoid organs studied. mRNA appears in both double (CD4+CD8+)- and single...
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Neuroimmunomodulation (1999) 6 (1-2): 51–55.
Published Online: 08 January 1999
... part we will recapitulate our findings according to which cholinergic agonists affect thymocyte apoptosis via a nicotinergic effect on thymic epithelial cells. In the second part we will present evidence that acetylcholine within the thymus is mainly derived from the thymocytes themselves...
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