... as an experimental model of arthritis. However, the ability of kaolin to cause arthritis and related immune responses when administered alone is unclear. We evaluated the contribution of prostanoids and sensory C-fibres (and their neuropeptide substance P) to kaolin-induced inflammation in the rat knee. Methods...

... for substance P (SP) and NPY. In several cases the SP IR nerve fibers were found in close proximity to the immunocytes. Electron microscopic investigation also revealed the close association between the IR nerve fibers and immunocompetent cells where the gap was 1 µm or even less. Conclusions: The close...

...Sergei Spitsin; Florin Tuluc; John Meshki; Jian Ping Lai; Richard Tustin III; Steven D. Douglas Objectives: Vapreotide, a synthetic analog of somatostatin, has analgesic activity most likely mediated through the blockade of neurokinin-1 receptor (NK1R), the substance P (SP)-preferring receptor...

...Robert J. McCormack; Ronald P. Hart; Doina Ganea Substance P (SP), one of the best characterized neurogenic mediators of immune hyperactivity, stimulates the production of a variety of cytokines, and acts as a general proinflammatory agent inducing proliferation and activation of immune cells...

..., substance P, somatostatin, and calcitonin gene related peptide will be discussed in detail. In addition, the effects of nerve growth factor on the immune system will be presented. Finally, a possible role for these neuropeptides in various diseases and its clinical relevance will be suggested. 15 02...

...Christine Christian; Mark Gilbert; Donald G. Payan The neuropeptide substance P (SP) is one of the principal mediators of neurogenic inflammation as well as a neurotransmitter in nociceptive affect neurons. The mechanisms by which binding of SP to its receptor stimulates diverse downstream biologic...

...Wei-Dong Wen; Fang Yuan; Jian-Lin Wang; Yi-Ping Hou Objective: The aim of this study was to determine whether intranasal administration of botulinum toxin type A (BTX-A) could relieve the typical symptoms of allergic rhinitis (AR) and alter substance P (SP)- and vasoactive intestinal peptide (VIP...

...-exacerbated allergic airway inflammation, we demonstrated a stress-mediating role for neurokinin-1 receptor, the main substance P (SP) receptor. Here, our aim was to investigate the influence of stress or exogenously applied SP on airway inflammation and on the local cytokine production of immune cells...

...Jill M. Manske; Summer E. Hanson Background/Objective: Substance P (SP) has been reported to have immunoregulatory properties including effects on many of the mediators involved in anti-tumor immunity. In this study, we investigated the effect of SP on tumor development in a murine model...

...Giorgio Santoni; Consuelo Amantini; Roberta Lucciarini; Marina Perfumi; Pierluigi Pompei; Mario Piccoli Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment...

... content of arginine vasopressin (AVP) due to the activity of substance P. In experimental allergic encephalomyelitis (EAE), another chronic stress model, the role of substance P action is not clear. In this paper we tried to clarify the role of substance P in Lewis rats, which are susceptible...

...Giorgio Santoni; Consuelo Amantini; Roberta Lucciarini; Pierluigi Pompei; Marina Perfumi; Massimo Nabissi; Stefania Morrone; Mario Piccoli Herein, we provide evidence of the expression and function of substance P (SP) and neurokinin-1 receptor (NK-1R) in the rat thymus. In situ hybridization...

... of substance P (SP)- and vasoactive intestinal polypeptide (VIP)-immunoreactive (IR) nerve terminals and the immunocytes during experimental colitis in the rat. A mild colitis was induced by a luminal enema containing trinitrobenzene sulfonic acid. The most severe inflammation was detected after 2 days...

...Si-Yun Ryu; Kyu-Shik Jeong; Won-Kee Yoon; Sang-Joon Park; Bit-Na Kang; Sung-Ho Kim; Bae-Keun Park; Sung-Whan Cho We have investigated whether lipopolysaccharide (LPS) induces substance P (SP) and somatostatin (SOM) in popliteal lymph nodes in vivo and whether macrophages are a source of SP and SOM...

... substance P (SP) is present in small, nonmyelinated, afferent fibers, the target of the neurotoxin, CAPS, a radioimmunoassay specific for SP was used to verify the loss of these nerve fibers. CAPS injections into the DLN resulted in a loss in SP concentration in the DLN, with no depletion of SP...

.... The aim of this study was to evaluate whether and if so how neuropeptides influence cytokine production by lymphocytes, especially T cells. We investigated the effects of neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP...

...William Fehder; Jonathan Sachs; Marina Uvaydova; Steven D. Douglas Peripheral blood concentrations of the proinflammatory peptide substance P (SP) have been shown to increase in response to psychological anxiety in human subjects. In this study, we examined changes in SP levels in peripheral blood...

...Ari S. Berman; Cheryl Chancellor-Freeland; Gaofa Zhu; Paul H. Black We have recently shown that substance P (SP) participates in the stress-induced modulation of elicited, peritoneal macrophage function. This study reports the in vitro effects of SP on macrophage activity. We show by an MTT...

... of these inflammatory cytokines on neurotransmitter gene expression in injured sympathetic ganglia. 8 3 1996 Interleukin-1 Superior cervical ganglion Substance P Leukemia inhibitory factor Interleukin-1 receptor Tumor necrosis factor-α © 1995 S. Karger AG, Basel 1996 Copyright / Drug Dosage...

...Galina Kataeva; Albert Agro; Andrzej M. Stanisz The proinflammatory peptide substance P (SP) has been shown to be intimately involved in the local inflammatory processes of Trichinella-spiralis- induced murine intestinal inflammation. Significant increases in SP, increased myeloperoxidase levels...