... in brain functions, may influence serotonin metabolism and appears to be associated with alexithymia. Healthy individuals carrying the long allele (L) of the serotonin transporter gene polymorphic region (5-HTTLPR), and thus having lower concentrations of serotonin in the synaptic cleft, show a greater...

... induced by the stressor [ 24 ] and the effects reported after social disruption-induced stress in mice [ 25 ]. Furthermore, we also aimed to analyze the levels and turnover rate of serotonin (5-hydroxytryptamine, 5-HT) in the olfactory bulbs of companions of ETB mice. Olfactory cues released by ETB mice...

...-inflammatory cytokines IL-6 and TNF-α, anti-inflammatory cytokine IL-10, cortisol, and the tryptophan metabolites 3-hydroxykynurenine (3-OH-KYN), kynurenic acid (KYNA), kynurenine, serotonin (5-HT) and 5-hydroxyindol acetic acid (5-HIAA). Blood samples were scheduled during baseline, and in week 28 of add...

...Wylla T. Ferreira-e-Silva; Bruno A. Galvão; Kelli N. Ferraz-Pereira; Célia B. de-Castro; Raul Manhães-de-Castro Objective: Nutritional restriction during lactation has long-term consequences on the functioning of neuroimmune systems. Receptors and transporter serotonin (5-HT) are present...

...Claudio A. Serfaty; Priscilla Oliveira-Silva; Adriana da Cunha Faria Melibeu; Paula Campello-Costa Tryptophan is an essential amino acid and metabolic precursor of serotonin. Serotonin is both a classical neurotransmitter and a signaling molecule that plays crucial roles in the development...

... , and serotonin concentration in lymphocytes were determined by HPLC. The HDRS score was significantly lower in patients receiving fluoxetine and folic acid compared with those receiving fluoxetine and placebo after 6 weeks of treatment (7.43 ± 1.65 vs. 11.43 ± 1.31, respectively; p = 0.04). Plasma homocysteine...

... and amygdalae are the frequent outcomes of the changes in the hypothalamic-pituitary-adrenal axis and the immune system. Such changes may provide evidence for the link between chronic depression and dementia in later life. Inflammation Pro-inflammatory cytokines Glucocorticoids Serotonin...

...L. Lima; S. Mata; M. Urbina Serotonin transporter, measured by the specific binding of [ 3 H]paroxetine, has been reported to be reduced in circulating lymphocytes of patients with major depression. Due to this observation, the objective of the present report was to determine the levels...

...Telésfora Sempere; Mary Urbina; Lucimey Lima Lymphocytes possess serotonin 5-HT 1A and β-adrenergic receptors, which have been related to cell proliferation. In the present report, lymphocytes of rat blood were isolated by Ficoll-Hypaque gradients and differential adhesion to plastic. They were...

...Jasminka Stefulj; Sanjica Jakopec; Maja Osmak; Branimir Jernej Objective: The apoptogenic potential of serotonin (5-hydroxytryptamine) on mitogen-stimulated lymphocytes was studied in primary cultures of rat spleen cells, in two sets of experiments. Methods: Apoptosis was measured by morphologic...

...Jasminka Stefulj; Lipa Cicin-Sain; Konrad Schauenstein; Branimir Jernej Objective: The effect of serotonin (5-hydroxytryptamine; 5HT) on the in vitro proliferation of mitogen-stimulated lymphocytes was studied in primary cultures of rat spleen cells. Methods: 5HT was added to the cultures 1 h prior...

...Trisha C. Pellegrino; Barbara M. Bayer Objectives: We have previously reported that acute administration of the specific serotonin reuptake inhibitor (SSRI), fluoxetine, resulted in a decrease in mitogen-induced blood lymphocyte proliferation. The present studies further examine the specificity...

... response. Immune activation has long been known to be a potent stimulator of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as brain catecholamine and indoleamine metabolism, involving increases in the brain concentrations of catabolites of norepinephrine (NE) and serotonin (5-HT), as well...

... amygdala, and reduced NE within the locus coeruleus. As well, serotonin (5-hydroxytryptamine; 5-HT) levels were altered within the hippocampus and prefrontal cortex, and dopamine turnover was reduced within the caudate and substantia nigra. The finding of altered central neurotransmitter activity needs...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. LPS IL-1 IL-1ra ACTH Corticosterone Norepinephrine Serotonin Tryptophan Original Paper Neuroimmunomodulation...

... Norepinephrine Serotonin Corticosterone Original Paper Neuroimmunomodulation 1999;6:319 329 Received: July 16, 1998 Accepted: August 11, 1998 Mouse Tumor Necrosis Factor-· Increases Brain Tryptophan Concentrations and Norepinephrine Metabolism While Activating the HPA Axis in Mice Tetsuya Ando Adrian J...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Endotoxin Norepinephrine Serotonin Interleukin-1 Interleukin-6 Tryptophan ...