...Hui Li; Weijia Du; Yawei Yuan; Jingjing Xue; Qiang Li; Long Wang Introduction: Numerous pieces of evidence demonstrated that isoflurane induces hippocampal cell injury and cognitive impairments. Picroside II has been investigated for its anti-apoptosis and antioxidant neuroprotective effects. We...

... as a potential neuroprotective agent for neurologic disorders such as PD, but the specific underlying mechanism remains unclear. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and primary astrocytes/neurons were prepared to investigate the effects of simvastatin on PD and its...

... Neuroprotection Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), which is characterized by sensory and visual disturbances, motor impairments, fatigue, pain, and cognitive decline [ 1, 2 ]. This disease is considered to be autoimmune, and T cells are involved...

...Samarah Cook; Vanessa Hung; Kelli A. Duncan Objectives: Characterized by neuroinflammation, traumatic brain injury (TBI) induces neuropathological changes and cognitive deficits. Estrogens are neuroprotective by increasing cell survival and this increase is mediated by a decrease...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Excitotoxicity Neuroprotection Motor neurons Chrna2 Microglial cells Neuronal...

... neuroprotective activities in experimental models of Parkinson and Alzheimer disease. This study aimed at assessing the neuroprotective role of BCG in a murine model of JE. Methods: Suckling mice were inoculated with 10 6 CFU of BCG and at 18 days postinoculation were challenged with 100 LD 50 of JEV. PBS...

... < 0.05, ** p < 0.01 vs. NT. Transglutaminase 2 Curcumin NF-κB Neurodegeneration Neuroinflammation Neuroprotection Transglutaminases (EC 2.3.2.13) are a family of calcium-dependent enzymes that catalyze the cross-linking of proteins by promoting the formation of isopeptide bonds...

...Henrik Hasseldam; Flemming Fryd Johansen Objectives: Multiple sclerosis can be characterized by a strong neuroinflammatory and progressive neurodegenerative component leading to prolonged disability. The synthetic compound R(+)WIN55,212-2 is reported to be neuroprotective at moderate doses and both...

... signaling Neuroprotection Alzheimer’s disease Neuroimmunomodulation 2010;17:202 204 DOI: 10.1159/000258724 Published online: February 4, 2010 Neuroimmunomodulation in the Pathogenesis of Alzheimer s Disease Inelia Morales Gonzalo Farías Ricardo B. Maccioni Laboratory of Cellular and Molecular...

... to reduce infarct size in acute stroke. Since edema treatment can provide secondary neuroprotective effects, we conducted the present study to evaluate whether edema reduction is the underlying cause of the neuroprotective properties of IVIG in experimental stroke. Methods: Male Wistar rats received either...

... 3 months postpartum, the suggestion was made that high levels of circulating sex steroids are responsible for pregnancy-mediated neuroprotection. As both estradiol (E 2 ) and progesterone exert neuroprotective and myelinating effects on the nervous system, the effects of sex steroids were studied...