... encephalomyelitis (EAE) led to a marked decrease in the incidence and clinical signs of the disease, and diminished delayed-type hypersensitivity (DTH) responses, proliferation following stimulation with the encephalitogenic myelin basic protein (MBP), anti-MBP antibody production and spinal cord histological...

... of Chagas’ disease present increased antibody production and proliferative responses to peripheral myelin components, such as myelin basic protein (MBP), which is homologous to the P1 protein fraction of peripheral myelin. T lymphocytes preferentially recognize a region on the MBP molecule (1–30), which...

... of the disease associated with castrated EAE animals. The clinical signs observed in the different groups correlated with changes in delayed-type hypersensitivity and mononuclear cell-proliferative responses to the encephalitogenic myelin basic protein. Moreover, testosterone but not cholesterol supplementation...

... susceptibility of this strain is associated with altered hypothalamo-pituitary-adrenal (HPA) function. Methods and Results: We observed that SJL/J mice display a strong humoral response to immunization with myelin basic protein (MBP), as assessed by the titration of circulating anti-MBP antibodies. However...

...T. Démoulins; L. Naccache; P. Clayette; P. Musette; D. Bequet; G. Gachelin; D. Dormont Anti-myelin basic protein (MBP) autoreactive T cells play a key role in the pathogenesis of multiple sclerosis. Thus, we applied the Immunoscope strategy to cerebrospinal fluid (CSF) and peripheral blood...