...Eduardo C. Zarzana; Alexandre S. Basso; Frederico A. Costa-Pinto; João Palermo-Neto Background: Mice allergic to ovalbumin (OVA) avoid drinking a solution containing this antigen. This was interpreted as related to IgE-dependent mast cell degranulation and sensory C fiber activation. Methods: We...

... that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to local and systemic allergen challenges in diabetic conditions. Moreover...

... with strong pruritogenic potential, such as nerve growth factor, corticotropin-releasing hormone and substance P, and mast cells, which may be considered as ‘central cellular switchboards of pruritogenic inflammation’, need to be further explored systematically in order to develop more effective therapeutic...

... important roles in neuronal dysfunction and in the pathogenesis of the nervous system diseases. CXCL8 (IL-8) is a CXC chemokine with chemotactic and inflammatory properties. Chemokines control mast cell infiltration in several inflammatory diseases, including stress and neurological dysfunctions. Using...

...Maria Luisa Castellani; Duraisamy Kempuraj; Stavros Frydas; Theoharis C. Theoharides; Isaia Simeonidou; Pio Conti; Jacopo Vecchiet Mast cells are important in reactions of allergic disease and are also involved in a variety of neuroinflammatory diseases. Mast cells can be immunologically activated...

...Yun-Xia Zuo; David J. Tracey; Carolyn Geczy Objective: Matrix metalloproteinases (MMPs) contribute to inflammatory and degenerative processes in injured nerves. Since mast cells release mediators which upregulate and activate MMPs, we tested the hypothesis that activation of mast cells...

...Jerome Gay; Jean Fioramonti; Rafael Garcia-Villar; Lionel Bueno Objectives: To determine whether intestinal mast cells and capsaicin-sensitive afferent nerves are involved in the development and sequels of Nippostrongylus brasiliensis -induced intestinal inflammation in rats. Methods: Two series...