... of major depressive disorder (MDD), but, so far, no specific investigation of chemokines exists. Methods: In this study, we investigated the changes of plasma chemokine levels (eotaxin-1, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, and TARC) in 47 MDD patients before (PRE) and after 1 and 6 weeks...

...Norbert Müller High levels of several proinflammatory components of the immune system, such as interleukin-6, C-reactive protein, tumor necrosis factor (TNF)-α, or neopterin in patients suffering from major depression (MD) point to the involvement of an inflammatory process in the pathophysiology...

..., instructions or products referred to in the content or advertisements. Folic acid Fluoxetine Homocysteine Lymphocytes Major depression Serotonin Original Paper Neuroimmunomodulation 2008;15:145 152 DOI: 10.1159/000151527 Received: January 25, 2008 Accepted after revision: May 9, 2008 Published...

... of depressed patients. The objectives of this work were to evaluate the basal proliferation of lymphocytes, the response to the mitogen concanavalin A, and the role of serotonin 5-HT 1A receptors. Twenty-nine patients, 19–52 years old, were diagnosed for a major depression episode with the Statistical...

...L. Lima; S. Mata; M. Urbina Serotonin transporter, measured by the specific binding of [ 3 H]paroxetine, has been reported to be reduced in circulating lymphocytes of patients with major depression. Due to this observation, the objective of the present report was to determine the levels...

... of dexamethasone were similar to saline-pretreated controls. These results suggest that LPS impairs the negative feedback of either endogenous or exogenous GC upon the adrenocortical response to stress. This finding may be relevant to the enhanced adrenocortical activity associated with sepsis and major depression...