... of iNOS and TNF-α in the spinal nerve roots, dorsal root ganglia and sciatic nerve of Lewis rats during experimental autoimmune neuritis (EAN). Methods: Macrophages and neutrophils were identified by immunofluorescence as cellular sources of iNOS and TNF-α at various stages of EAN induced by synthetic...

... in hippocampus of aged and lipopolysaccharide (LPS)-treated rats. Methods/Results: We report that a possible initial target cell of the putative anti-inflammatory actions of VP025 may be macrophages, as VP025 is engulfed by, and has the capacity to alter the activity of, these cells. VP025 reversed the increase...

... in macrophages and may influence their role. This study evaluated nitric oxide release by alveolar macrophages (AMs) in adult control rats and rats malnourished during lactation in response to different fluoxetine (FLX) concentrations and 5-HT 1A and 5-HT 1B agonists at different times. Methods: Male Wistar rats...

... of this involvement remain largely unclear. In this study, we found that GnRH increased the intracellular calcium levels in murine Raw264.7 macrophages. Furthermore, the production of nitric oxide, costimulated with lipopolysaccharide and interferon-γ, was suppressed by exposure to GnRH. Moreover, the modulatory...

...Glaucie Jussilane Alves; Luciana Vismari; João Palermo-Neto The present study was designed to evaluate the effects of mice cohabitation with a sick conspecific cage mate on peritoneal macrophage activity and on resistance to Ehrlich tumor growth. Female mice housed in pairs were divided...

...Si-Yun Ryu; Kyu-Shik Jeong; Won-Kee Yoon; Sang-Joon Park; Bit-Na Kang; Sung-Ho Kim; Bae-Keun Park; Sung-Whan Cho We have investigated whether lipopolysaccharide (LPS) induces substance P (SP) and somatostatin (SOM) in popliteal lymph nodes in vivo and whether macrophages are a source of SP and SOM...

...Ari S. Berman; Cheryl Chancellor-Freeland; Gaofa Zhu; Paul H. Black We have recently shown that substance P (SP) participates in the stress-induced modulation of elicited, peritoneal macrophage function. This study reports the in vitro effects of SP on macrophage activity. We show by an MTT...

...Cai Song; Brian E. Leonard The macrophage theory of depression proposes that abnormal secretions of the macrophage cytokines, an increase in interleukin (IL) 1, and a decrease in IL-2 may cause depression. The olfactory bulbectomized (OB) rat has been developed as an animal model of depression...