... to lipopolysaccharide (LPS) and its subsequent effects on cognitive functions. Methods: To this end, male rats were tested through a Morris water maze (MWM) to assess their spatial learning and memory. Also, in vivo field potential recordings (to evaluate synaptic plasticity) were done in the Saline, SD, LPS1 (1 mg/kg...

... symptomatology. Moreover, a single inflammatory episode is not sufficient to alter diurnal cortisol profiles, as observed in inflammation-associated depression. In addition, the absence of persistent lipopolysaccharide-induced psychological and physiological changes beyond the acute phase further supports...

... to in the content or advertisements. 2023 Inflammation Lipopolysaccharide Cytokines Sickness behavior Pain DFG Human experimental models of systemic immune activation give scientists an opportunity to study the direct and causal effects of inflammation on behavior and underlying brain...

... necrosis factor α Interleukin 10 Lipopolysaccharide We will now try to present what we consider the most crucial pieces of evidence that support Besedovsky’s original theory: that sympathetic nerves are the motor arm of an endogenous neural reflex, now usually termed the inflammatory reflex [ 6...

... neurodevelopmental alterations that lead to neuropsychiatric disorders such as autism spectrum disorder (ASD). Previous evidence points to long-term behavioral consequences, such as autistic-like behaviors in rodents induced by lipopolysaccharide (LPS) pre- and postnatal (PN) exposure during critical...

.... Inflammatory processes are likely involved in its pathophysiology, but the underlying mechanisms have remained uncertain. Here, we used the model of systemic lipopolysaccharide (LPS) injection to test the hypothesis that depressive-like behaviors occur along with changes in the levels of cytokines and brain...

...Amanda Florentina do Nascimento; Brooke Thompsom; Paulo Ricardo Dell’Armelina Rocha; Shelley Kirychuk; Maria Martha Bernardi; Luciano Freitas Felicio Objective: Previously we observed an attenuation of body temperature in lactating rats treated with lipopolysaccharide (LPS) compared with virgin...

...Amanda Fiorentina Nascimento; Shelley Kirychuk; Maria Martha Bernardi; Luciano F. Felício Objectives: Previous studies from our group showed that lipopolysaccharide (LPS) exposure induces several signs of sickness behavior, including a decrease in food consumption, body weight gain, adipsia...

... underwent the established peripheral euflammatory protocol or vehicle treatment, followed by an acute peripheral immune challenge (lipopolysaccharide [LPS] injection) or PBS. Cognitive function and sickness behavior were assessed after the challenge, and peripheral and central inflammatory responses were...

... anxiety when immune-stimulated. Chronic mild brain inflammation and a pro-inflammatory microglial activation is critical in psychiatric behaviour. Objective: To explore brain/microglial activation and behaviour in NOD mice at steady state and after systemic lipopolysaccharide (LPS) injection. Methods...

... mechanism for immunomodulation remains to be elucidated. The present work describes the role of the hypothalamic-pituitary-adrenal (HPA) axis in the mechanism of stress-mediated enhanced-resistance to lethality after lipopolysaccharide (LPS) injection. Methods/Results: Preconditioning with restraint stress...

... and endocrine tissues during SIRS. Methods: Wild-type (wt) and casp1 knockout (casp1 -/- ) mice were injected with either saline or a high dose of endotoxin/lipopolysaccharide (LPS; 800 μg/mice i.p.). Saline-injected mice were immediately euthanized after injection, whereas LPS-injected mice were sacrificed 6...

... that monocytes (MOs) and macrophages (MPs) could be the target of anti-inflammatory actions of OT. Here, we present a series of ex vivo experiments in human MOs and MPs, testing whether OT attenuates the cytokine responses of these cells to a common bacterial product, lipopolysaccharide (LPS). Methods: MO...

...Amanda Nascimento; Maria Bernardi; Vanessa Pecorari; Christina Massoco; Luciano Felicio Objectives: Lipopolysaccharide (LPS), an endotoxin that originates from the cell wall of Gram-negative bacteria, activates the immune system to release proinflammatory cytokines and to induce sickness behavior...

... by lipopolysaccharide (LPS). This study was to test the hypothesis that cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor-α are associated with aggravated neuronal damage. Materials and Methods: Sixty male Sprague-Dawley, 14-day-old rats were used. Experiments were conducted in saline, LPS + saline...

...) in saline- and lipopolysaccharide-treated mice. Methods: Adult inbred mice were paradoxical sleep deprived (72 h), whereas the controls were kept in their home cages. After PSD, both groups received an injection of either saline or lipopolysaccharide (LPS; 1 or 5 µg/animal, intraperitoneally), 2 h prior...

... with bacterial lipopolysaccharide (LPS; 25 µg/kg body weight, i.v.) and bled for up to 4 h. Data indicate that (1) ODX increased peripheral glucocorticoid levels and reduced those of testosterone, whereas FTM-treated rats displayed low circulating leptin concentrations, and (2) LPS-induced TNFα secretion...

...) and, undernourished (8% casein, LP diet). On postnatal day 63, the animals were submitted to moderate physical training (8 weeks, 5 days·week –1 , 60 min·day –1 , at 70% of V O 2max ). After the physical training period, half of each group received an injection of either lipopolysaccharide (LPS) or saline. Plasma...

... inflammatory mediator responding to lipopolysaccharide (LPS). It has been stated that the constitutive NO synthase isoforms (nNOS and eNOS) may also contribute to the inflammation. CAPON, a nNOS regulator, helps regulate nNOS stability, localization and possibly expression during synapse formation as well...

... studied in intact and ovariectomized mice. Endotoxemia was mimicked by intraperitoneal administration of bacterial lipopolysaccharide (LPS; 25 mg per mouse) to sham-operated and 21-day ovariectomized mice. Circulating corticosterone, tumor necrosis factor-α (TNFα) and leptin concentrations were monitored...