... and peripheral blood mononuclear cell (PBMC) production of LPS-stimulated inflammatory mediators. Results: Plasma soluble CD40 ligand and stimulated MIP-1α production were both reduced (p ≤ 0.05) by systemic β-adrenergic stimulation. Stimulated TNF-α production was reduced (p < 0.03) but plasma TNF-α...

... of IL-1RAcP. Animals were injected intraperitoneally with rat recombinant IL-1β (200 ng/mouse), lipopolysaccharide (LPS, 5 µg/mouse), or subjected to 1-hour restraint stress. Neuroendocrine and immune parameters were measured 2 h after IL-1 or LPS injection or just after restraint. In wild-type controls...

...Adrian J. Dunn; Artur H. Swiergiel Administration of interleukin-1 (IL-1) and endotoxin (lipopolysaccharide, LPS) to rodents can decrease food intake, a behavioral response resembling the diminution of appetite observed in human depression. IL-1 and LPS are known to affect cerebral...

..., corticosterone, tumor necrosis factor-α (TNF) and leptin (LEP) levels were determined in basal condition and 2 h after endotoxin (LPS; 180 µg/kg body weight, i.p.) administration in 3 different groups: (1) well-nourished (WN) controls; (2) undernourished (UN) rats as a consequence of chronic food restriction...

...Adrian J. Dunn Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism. Because LPS administration is known to induce the synthesis and secretion of IL-1...