...Shraddha Mehta; Sandeepan Mukherjee; Deepa Balasubramanian; Abhay Chowdhary Objective: Recombinant human interferon (rhIFN)-α is a potent immunoregulator having a wide range of therapeutic applications. In the present study, rhIFN-α was evaluated for its neuroimmunomodulatory activity. Method: Dose...

... increased after treatement of dwarf mice with GH. The immune system of dwarf mice receiving spleen cells, however, was significantly altered. Spleen cells from dwarf animals showed enhanced immunoglobulin, interleukin (IL)-6, IL-2, and interferon-Γ production whereas no significant change was apparent...

...Dirk Reske; Anne V. Thomas; Hela-Felicitas Petereit; Gereon R. Fink; Michael Schroeter Objectives: Treatment with interferon(IFN) β, glatiramer acetate (GLAT) and intravenous immunoglobulins (IVIG) alters the cytokine production in multiple sclerosis (MS) patients. To date, it is not clear whether...

... uptake activity. Interleukin (IL)-1β and tumor necrosis factor-α dose-dependently inhibited astrocyte glutamate uptake, whereas interferon (IFN)-γ alone stimulated this activity. The nitric oxide synthase inhibitor, N G -monomethyl- L -arginine, blocked IL-1β-mediated inhibition of glutamate uptake...

...Audrius V. Plioplys; Nicolas Massimini We investigated the effect of alpha/beta interferon on neuronal survivability. E16 murine telencephalic vesicles were dissected aseptically and grown on collagen-coated coverslips. After 2 weeks of culturing, the media was supplemented with mouse alpha/beta...