...Laura Esteves Petersen; Rodrigo Grassi-Oliveira; Talita Siara; Suyan Gehlm Ribeiro dos Santos; Mariana Ilha; Tatiana de Nardi; Mauro Keisermann; Moisés Evandro Bauer Background: Rheumatoid arthritis (RA) has been associated with premature immunosenescence and an increased prevalence of age-related...

...Bruna Luz Correa; Ana Paula Ornaghi; Guilherme Cerutti Muller; Paula Engroff; Rodrigo Pestana Lopes; Irênio Gomes da Silva Filho; Jos A. Bosch; Cristina Bonorino; Moisés Evandro Bauer Background: Some premature features of immunosenescence have been associated with persistent viral infections...

... between sympathetic activity and immunosenescence. Objectives: The aim of this study is to investigate the effects of l -(–)-deprenyl, a monoamine oxidase-B inhibitor, on the sympathetic nervous system and cell-mediated immune responses in old female rats. Methods: Low doses of l -deprenyl (0.25 or 1.0 mg...

...) and obesity. In all cases, the prematurely aged animals suffer an alteration of the nervous system (shown by behavioral tests) and immunosenescence as well as oxidative and inflammatory stress, which is followed by early mortality. In addition, in the above-mentioned models and in normal chronological aging...

...Daniel P. Cardinali; Ana I. Esquifino; Venkataramanujan Srinivasan; Seithikurippu R. Pandi-Perumal Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate...

..., especially in males. This supports the hypothesis of a premature immunosenescence as a pathogenically relevant factor in AD which was found to be enhanced in the 3×Tg-AD males, suggesting that this could also be responsible for the increased morbidity and mortality of these subjects. Therefore, future...

...Gerald Pfister; Wilson Savino The continuous global increase in life expectancy represents a central challenge for our society and impacts public social security systems, families and individuals. One of the most striking changes that occur during normal human aging is immunosenescence...

... (immunosenescence) do not represent a simple unidirectional decline in all functions but develop as a complex remodeling of the immune system, involving multiple reorganization and developmentally regulated changes. In general, most data available about aging were obtained at particular age intervals and most...

... to cope with a lifelong and evolutionarily unpredicted exposure to a variety of antigens, which are at the basis of profound age-related changes globally indicated as immunosenescence, a multifaceted phenomenon that increases morbidity and mortality due to infections and age-related pathologies. The major...

...Moisés Evandro Bauer This paper reviews recent work suggesting that human immunosenescence may be closely related to both chronic stress and stress hormones. The age-related immunological changes are also similarly found during chronic stress or glucocorticoid exposure. These data further suggest...

... on the changes of the immune system with age, denominated immunosenescence, the data supporting the role of this system in aging are very scarce. With aging, the immune cells show an increase in oxidant and inflammatory compounds and a decrease in antioxidant defenses, which is more evident in phagocytic cells...

... levels of brain biogenic amines as well as immunosenescence and decreased life span, when compared to their control counterparts, which quickly explore the maze. These traits are similar to some of the alterations previously observed in aging animals and therefore we proposed that those ‘slow mice...

... to in the content or advertisements. Aging Glucocorticoids Immunosenescence Lymphocytes Psychoneuroimmunology Original Paper Neuroimmunomodulation 2006;13:160 169 DOI: 10.1159/000097535 Received: June 26, 2006 Accepted after revision: October 5, 2006 Published online: November 30, 2006 Healthy Aging...