... that chronic stress induces immune suppression by targeting TLR2 and p38 MAPK in naive CD4+ T cells. Toll-like receptor (TLR)2, which plays a critical role both in the innate and adaptive immune responses [ 11,12 ], is involved in regulating the differentiation of Th17 cells from naive CD4+ T cells [ 13...

... blocked the chronic stress-induced imbalance in T helper (Th) 1 and Th2 cytokine levels. Conclusion: Taken together, our findings reveal that TLR9 plays an essential role in chronic stress-induced immune suppression. 27 03 2013 16 07 2013 24 9 2013 © 2013 S. Karger AG, Basel 2013...

..., respectively). Conclusion: These data suggest that exhaustive exercise-induced suppression of the plasma TNF-α concentration despite LPS stimulation might depend on translation of TNF-α in tissues. Immune suppression Tumor necrosis factor-α TNF receptors Lipopolysaccharide Toll-like receptor 4 14...