... changes of anti-inflammatory cytokines in the hippocampus. Genes associated with anti-inflammatory signaling that were analyzed included Il10 , Tgfb1 , Il4 , and IL-4-responsive genes, Cd200 , Cd200r1 , and Mrc1 ( Cd206 ). Results: Oral LGG administration altered the abundance of CSF proteins, increasing...

...Weiqing Shi; Wenbing Zhang; Jinping Wang Introduction: Isoflurane-associated perioperative neurocognitive disorders (PNDs) is a common complication that occurs commonly in elderly patients characterized by deterioration of hippocampus-dependent cognitive function. Mounting evidence has shown...

... of their seizures after the administration of ≥2 pharmaceuticals. Here, we aimed to observe the ultrastructure changes and the expression of ZnT3 and GFAP in the hippocampus of drug-resistant epileptic rats. Methods: A total of 50 healthy adult male SD rats were used to generate the model ofepilepsy by amygdala...

... in the dentate gyrus, spinogenesis, and glutamatergic synaptic function in the CA of the hippocampus. Hippocampus plasticity is particularly involved in the brain effects of the enriched environment (EE), and interestingly CD4 + and CD8 + T cells play essential and differential roles in these effects. However...

... binge drinking in nondependence has not been readily assessed. These studies seek to determine how the neuroimmune system within the hippocampus responds to binge-like consumption prior to dependence or evidence of brain damage. Methods: C57BL/6J mice underwent the drinking in the dark (DID) paradigm...

...) at an early age affects the response of the neuroimmune system. Here we investigated the effect of periodic maternal separation (MS) followed by administration of lipopolysaccharide (LPS) on glial cells in the CA3 region and hilus of the hippocampus and on cytokine release on postnatal day (PN) 15. Methods...

... in the BCCAO group showed cognitive deficits, accompanied by oxidonitrosative stress, neuroinflammation, and a reduction in brain-derived neurotrophic factor (BDNF) in the hippocampus region. Moreover, the acetylcholinesterase activity in the hippocampus was found to be increased in the BCCAO group compared...

... predator behaviors. Objective: The present study was conducted to characterize short-term memory and depression-like behavior, as well as levels of neurotransmitters and cytokines in the hippocampus of cysticercotic male and female mice. Methods: Cytokines were detected by RT-PCR and neurotransmitters were...

... in the hippocampus, which plays an important role in the regulation of the feedback effect of GCs, may cause abnormal HPA axis responses following BI. 6 06 2012 9 08 2012 23 11 2012 © 2012 S. Karger AG, Basel 2012 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... in the mouse hippocampus under basal conditions and following stimulation with in vivo bacterial lipopolysaccharide (LPS, 250 µg/kg i.p.). Methods: IL-1β levels were determined in the hippocampi of wild-type (WT), CB1R–/– and P2X 7 receptor (P2X 7 R)–/– mice using an ELISA kit. Results: Basal but not LPS...

..., but also between strains. MR B max in the hippocampus and pituitary was lower in LEW/N than in F344/N, whereas the GR B max in the LEW/N thymus was greater than that found in F344/N rats. The hippocampal levels of MR mRNAs in Adx LEW/N and F344/N rats were in good agreement with, and paralleled...

... and adult tissues of the rat, including the brain. However, there have been conflicting reports on the distribution of SCF mRNA in adult rat brain. Specially noteworthy was one report of the absence of SCF mRNA in adult hippocampus, while another group reported the presence of that mRNA in the dentate gyrus...

... IL-1 type-I receptor (IL-1RI) has permitted us to conduct an in situ hybridization study using a species-specific, 35 S-labeled anti-sense riboprobe to localize IL-1 receptor mRNA in rat brain. We localized IL1-1RI mRNA in the hippocampus, choroid plexus, and cerebellum. At the cellular level we...

..., instructions or products referred to in the content or advertisements. T cells Volatile organic compounds Learning ability Hippocampus Rapid Communication Neuroimmunomodulation 2010;17:132 134 DOI: 10.1159/000258697 Received: May 8, 2009 Accepted: July 31, 2009 Published online: November 17, 2009...

... with an increase in the concentration of the inflammatory cytokine interleukin-1β (IL-1β) in the hippocampus and an inhibition in long-term potentiation. Objectives: To assess the effects of a novel preparation of phospholipid nanoparticles incorporating phosphatidylglycerol, VP025, on inflammatory changes...

... to this alteration, together with elevated adrenal glucocorticoids and prominent susceptibility to stress. In the hippocampus of diabetic animals a marked astrogliosis, often associated with neural damage, was present. Dentate gyrus neurogenesis was also affected by the disease: proliferation and differentiation...

... the survival and maintenance of neurons, in the hippocampus of immunized mice. In the present study, we examined the effects of FA on apoptotic mechanisms regulating survival and death of cells and on N-methyl- D -aspartate (NMDA) receptors related to hippocampal functions in the mouse hippocampus. Methods...

..., prevents several LPS-induced inflammatory changes in the hippocampus. Here, we investigated neuroprotective effects of IMT in cortical tissue, and report that the treatment acts as an anti-inflammatory and antioxidative agent, reducing the concentration of TNFα and the accumulation of reactive oxygen...

...Hidekazu Fujimaki; Yoshika Kurokawa; Masaki Kakeyama; Naoki Kunugita; Yukiko Fueta; Takaichi Fukuda; Hajime Hori; Keiichi Arashidani Objective: The effects of low-level formaldehyde (FA) inhalation on the amount of nerve growth factor (NGF) in the hippocampus of immunized mice were studied. Methods...

...Yvonne Nolan; Aedín Minogue; Emily Vereker; Anthony E. Bolton; Veronica A. Campbell; Marina A. Lynch Systemic injection of lipopolysaccharide (LPS) blocks the expression of long-term potentiation in the hippocampus of the rat. This is coupled with increased IL-1β concentration and c-Jun NH 2...