... not just the sympathetic innervation and neurotransmitter release, but also modifying the thymus microenvironment and T-cell development. We used the well-established multiple sclerosis model of experimental autoimmune encephalomyelitis (EAE), to study putative changes in the thymic neural, lymphoid...

... like MS. Methods: Thus, our study applied an experimental autoimmune encephalomyelitis (EAE) mouse model and examined the effects of CBX on it. Results and Conclusions: We found that CBX significantly reversed the EAE severity and pathology in EAE. IL-17-secreting and IFN-γ-secreting CD4+ T lymphocytes...

...Evangel Kummari; James M. Nichols; Eun-Ju Yang; Barbara L.F. Kaplan Objectives: The active experimental autoimmune encephalomyelitis (EAE) model is often initiated using myelin oligodendrocyte glycoprotein (MOG) immunization followed by pertussis toxin (PTX) to study multiple sclerosis. However...

...Ivan Pilipović; Ivana Vujnović; Raisa Petrović; Zorica Stojić-Vukanić; Gordana Leposavić Objective: We examined the effect of β-adrenoceptor (AR) blockade in the preclinical phase of experimental autoimmune encephalomyelitis (EAE), the most commonly used model of multiple sclerosis...

... of the BBB was induced by intracarotid injection of mannitol (25%). Experimental autoimmune encephalomyelitis (EAE) was induced by brain homogenate. The extent of disruption was evaluated by Evans blue (2%) dye extravasation. Results: L-NAME (a nonspecific NOS inhibitor) and SMT (a neuronal and endothelial...

...Nicolás Fernández Hurst; Mario J. Bibolini; German A. Roth Objective: Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to human multiple sclerosis involving peripheral activation of autoreactive T cells which infiltrate the central nervous...

... actin cytoskeleton and is essential for cell motility and adhesion, neurite outgrowth and retraction. In chronic disabling disease, multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), demyelination and axonal damage are the major pathological changes...

...Yawei Guo; Koon-Ho Chan; Wing-Hon Lai; Chung-Wah Siu; Shing-Cheong Kwan; Hung-Fat Tse; Philip Wing-Lok Ho; Jessica Wing-Man Ho Background/Aims: Multiple sclerosis (MS) causes significant neurological disability. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. Human bone...

... Experimental autoimmune encephalomyelitis Metallothioneins I/II Zinc Copper Metallothioneins (MTs) belong to a highly conserved family of low molecular weight, cysteine-rich proteins [ 1,2,3,4,5,6 ]. As zinc- and copper-binding proteins they are involved in several physiological processes...

... thoroughly examined. Objectives: We evaluated the delayed effects of irradiation on the course of experimental autoimmune encephalomyelitis (EAE), which is used as a model for neuroimmune inflammation and multiple sclerosis. Methods: Adult male rats were exposed to a dose of 15 Gy given to the thoracolumbar...

... model of experimental autoimmune encephalomyelitis (EAE). Methods: The rat EAE model was induced by subcutaneous injection of guinea pig spinal cord homogenate. Rats received fluoxetine via daily intragastric administration, starting 2 weeks prior to immune induction (fluoxetine pretreatment). Clinical...

... of sertraline in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. Methods: Mice (C57/bl EAE) were treated with sertraline (5 mg/kg) or dexamethasone (1 mg/kg) 7 days after EAE induction and then 3 times weekly (for 3 weeks). Results: Sertraline modestly improved the clinical score...

... of a previous immunization with DNAhsp65 in the development of experimental autoimmune encephalomyelitis (EAE), a rat model of multiple sclerosis. Methods: Female Lewis rats were immunized with 3 pVAXhsp65 doses by intramuscular route. Fifteen days after the last DNA dose the animals were evaluated for specific...

... on the inflammatory profile in CNS during first relapse and related this to demyelination, axonal degeneration and relapse severity. Methods: Experimental autoimmune encephalomyelitis was induced in Dark Agouti rats and treatment with R(+)WIN55,212-2 was initiated at symptom debut. The animals were scored clinically...

..., instructions or products referred to in the content or advertisements. Dendritic cells Multiple sclerosis Neuroinflammation Experimental autoimmune encephalomyelitis Galectin-1 Interleukin-27 Interleukin-10 Neuroimmunomodulation 2010;17:157 160 DOI: 10.1159/000258712 Published online: February 4...

... in the experimental autoimmune encephalomyelitis (EAE) model of MS. Methods: EAE was induced in female C57BL/6 mice by administration of a myelin oligodendrocyte protein (MOG 40–45 ) peptide. Clinical signs of EAE, myelin protein expression and neuronal parameters were determined in mice with or without hormonal...

... relapses. Furthermore, studies employing the MS animal model experimental autoimmune encephalomyelitis have shown that certain stressors can exacerbate the disease if administered prior to disease induction. Several lines of research have explored the 2 major stress response systems – the hypothalamic...

...Andrzej R. Glabinski; Vincent K. Tuohy; Richard M. Ransohoff Experimental autoimmune encephalomyelitis (EAE) is an investigator-initiated disorder that serves as an animal model for the common human demyelinating disease multiple sclerosis. Both diseases are typified by disseminated perivascular...