... disorders, including major depressive disorder (MDD). Here, we investigated associations of circulating levels of the steroid hormone dehydroepiandrosterone (DHEA) with immune cell telomere length (TL) in the context of lifetime trauma exposure and MDD. Methods: Lifetime traumatic events (trauma load) were...

...Riley G. McCready; Kayla R. Gilley; Laura E. Kusumo; Grace M. Hall; Elisabeth G. Vichaya Introduction: Among chronically ill populations, affective disorders remain underdiagnosed and undertreated. A high degree of comorbidity exists between diabetes and affective disorders, particularly depression...

... behavior and inflammation-associated depression. Previous studies using this model revealed a strong association between cytokine levels, endocrine changes, and psychological sickness symptoms during the acute phase of inflammation. The objective of this randomized, double-blind, placebo-controlled...

... polymerase chain reaction was used to determine the common variants of the β2AR at position 16, 27, and 164 in 92 German RA outpatients. Health Assessment Questionnaire (HAQ-DI), Beck Depression Inventory (BDI), Perceived Stress Questionnaire (PSQ-30), Multidimensional Fatigue Inventory (MFI-20) were...

... or depression-like behavior is unknown. This study evaluated whether and how IL-10 attenuated chronic IL-1β administration-induced behavioral changes and the possible involved mechanisms. Methods: Rats received intracerebroventricular injection of IL-1β and/or IL-10 for 14 days. Then animal memory...

...Susana Silberstein; Ana Clara Liberman; Paula Ayelén dos Santos Claro; Maria Belén Ugo; Jan M. Deussing; Eduardo Arzt Depression and other psychiatric stress-related disorders are leading causes of disability worldwide. Up to date, treatments of mood disorders have limited success, most likely due...

... by several social psychologists and is confirmed to have benefits in the recovery of various diseases. This research aimed to explore the effects of the HBM-based intervention on anxiety, depression, and quality of life in COPD patients entering pulmonary rehabilitation (PR). Methods: This research...

...Minoo Safari-Arababadi; Mohammad Hossein Modarressi; Mahmood Sheikhfatholahi; Mahdi Khaleghinia; Mohammad Kazemi Arababadi Background: Depression and anxiety can modulate immune-related molecule expressions. The chronic HBV-infected (CHB) patients suffer from inappropriate immune responses...

...Janine Karina Hideko Alfenas Horita; Maria Carolina Machado da Silva; Carolina Zaniboni Ferrari; Erica Leandro Marciano Vieira; Fabricio A. Moreira; Antônio Carlos Pinheiro de Oliveira; Helton José Reis Introduction: Major depressive disorder is considered a global public health problem...

... in brain repair. In the second section, we present data of neuroinflammation and neurodegenerative disorders and discuss the role of reactive astrocytes in motor neuron toxicity and the progression of amyotrophic lateral sclerosis. In the third section, we discuss major depressive disorders...

...Daniela Krause; Theresa M. Stapf; Verena B. Kirnich; Anika Hennings; Sabine Riemer; Agnieszka Chrobok; Daniel R. Fries; Francisco Pedrosa Gil; Winfried Rief; Markus J. Schwarz; Ralf Schmidmaier Objective: Cellular immune status in major depression (MD) patients differs from that in somatoform...

... models of social stress indicate that recent thymic emigrant cells (RTE), which maintain the T-cell compartment, are affected. Methods: In this study, we examined the association between lymphocyte subsets, and depression and posttraumatic stress disorder (PTSD) among 16 maltreated children (aged 6-17...

... subjects. We examined whether the levels of adiponectin (μg/ml) and resistin (ng/ml) are independently related to alexithymic features in a population-based sample. Methods: In 2005, clinical data including laboratory assessments were obtained from a sub-sample (n = 308) of the Kuopio Depression Study...

... they are associated with high morbidity and mortality. A growing body of evidence suggests the existence of a link between inflammatory-immune responses and the occurrence of depression and cognitive impairment in PD patients. However, not all data are equally conclusive and are sometimes even conflicting. The aim...

...Eleonore Beurel Accumulative evidence shows a role of the immune system in susceptibility to depression. Proinflammatory cytokines have been shown to be involved in the induction of depressive behavior both in humans and mice, opening a new avenue of therapeutic strategy. Because glycogen synthase...

...Cristiano Noto; Lucas B. Rizzo; Rodrigo B. Mansur; Roger S. McIntyre; Michael Maes; Elisa Brietzke In the last decades convergent findings from several lines of evidence has revealed a robust association between major depressive disorder (MDD) and inflammatory pathways. Despite...

..., suggesting an epigenetic autoimmune susceptibility [ 7 ]. Together these findings suggest a link between autoimmunity and BD. Based on the very first evidence of leukocyte changes in major depression, some researchers evaluated the total number and subpopulations of white blood cells from BD patients...

...Min Hong; Jie Zheng; Zhao-yun Ding; Jun-hao Chen; LiangYan Yu; Yan Niu; Yong-qing Hua; Ling-ling Wang Background: Recent data suggest that major depression is potentially associated with dysregulated cytokine production. However, the roles of T helper (Th) cells and their subsets in the development...

...Ehud Baharav; Meytal Bar; Michal Taler; Irit Gil-Ad; Leon Karp; Abraham Weinberger; Avraham Weizman Objective: Previous studies suggest that selective serotonin reuptake inhibitors (SSRIs) modulate immune system functionality. SSRIs are the preferred treatment for major depressive disorder (MDD...

...Francisco Briceño; José Luis Arcaya; Edgardo Carrizo; Jaimar Rincón; Jesús Mosquera Objectives: Previous reports have shown that the depressive status in humans and experimental animals is associated with decreased immune response. Since monocyte chemotaxis and expression of CD11a are pivotal...