... statistically analysed using general linear models in R. Results: Both treatments showed signs of sickness behaviour following LPS administration, but the two treatments did not differ in the frequency, severity of sickness behaviours, or length of recovery or in the blood plasma concentration of cytokines...

... (HPA) axis to release glucocorticoids to levels that can exert immunoregulatory effects; (c) immune products, later identified as cytokines, mediate this effect. On these bases, the existence of a glucocorticoid-mediated immunoregulatory circuit was proposed. It was also shown that increased levels...

... not been fully appreciated until the late 1900s, when a growing interest in how cytokines in the cerebrospinal fluid (CSF) might be relevant in chronic pain conditions emerged. Since then, the field has evolved, and nowadays neuroinflammation is considered to be involved in the pathophysiology of chronic...

... individuals with a low-grade systemic inflammation. Methods: We collected the axillary body odour of individuals with severe seasonal allergy ( N = 14) and healthy controls ( N = 10) during and outside the allergy season and measured serum levels of two inflammatory cytokines (tumour necrosis factor-α...

... behavior and inflammation-associated depression. Previous studies using this model revealed a strong association between cytokine levels, endocrine changes, and psychological sickness symptoms during the acute phase of inflammation. The objective of this randomized, double-blind, placebo-controlled...

... able to clarify so far. We report that experimental endotoxemia results in a reproducible increase in pain sensitivity, particularly for pressure and visceral pain (deep pain), which is reflected in responses of brain areas involved in pain processing. Increased levels of blood inflammatory cytokines...

..., applying the established model of neuro-glial primary cell cultures of the superficial dorsal horn (SDH). We studied effects of gabapentin and pregabalin on lipopolysaccharide (LPS)-induced cytokine release (bioassays), expression of inflammatory marker genes (RT-qPCR), activation of transcription factors...

... of the vagus nerve produces anti-inflammatory effects; however, data on humoral immune responses of transcutaneous vagus nerve stimulation (tVNS) are rare. Therefore, the present study investigated changes in serum cytokine concentrations of interleukin-1β (IL-1β), IL-6, IL-8, and tumor necrosis factor α (TNFα...

... was induced by cecal ligation-puncture (CLP) surgery. Naive or animals that survive 5 or 10 days after CLP were submitted to lipopolysaccharide (LPS) injection or restraint stress. After 60 min, blood was collected for plasma nitrate, cytokines, adrenocorticotropic hormone (ACTH), and corticosterone (CORT...

...Moisés E. Bauer; Antônio L. Teixeira Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with increased plasma levels of pro-inflammatory mediators targeting all tissues including the brain. Importantly , pro-inflammatory cytokines (ex., tumor-necrosis factor alpha...

...Qiliang Li; Hong Jin; Ying Liu; Yu Rong; Tana Yang; Xiaolu Nie; Wenqi Song Objective: Methylmalonic acidemia (MMA) is the most common organic acidemia in children. Many patients with MMA suffered from cognitive impairments. The aim of this study was to identify the significance of cytokines...

... of caveolin-1 , ANGPTL7 , the glaucoma markers, and cytokines. Results: We demonstrated a significant increase in the expression of glial fibrillary acidic protein, ANGPTL7, with altered mitochondrial enzymes in glaucoma cells compared to the control. Moreover, cells predisposed to hydrostatic pressure...

.... IL-4 and IFN-γ cytokines were measured pre-experiment (preEX), immediately postexercise (IpostEX), and 72-h postexperiment protocol (72hpostEX). Results: There were no significant differences between the study groups regarding IFN-γ, IL-4, and IL-4/IFN-γ in preEX ( p > 0.05), IpostEX ( p > 0.05...

.... Inflammatory processes are likely involved in its pathophysiology, but the underlying mechanisms have remained uncertain. Here, we used the model of systemic lipopolysaccharide (LPS) injection to test the hypothesis that depressive-like behaviors occur along with changes in the levels of cytokines and brain...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. HTLV-1 T lymphocytes Integrins VLA-4 (CD49d) Cytokines Infection by the human T-cell lymphotropic virus type...

...Eleonora Sacchinelli; Fabrizio Piras; Maria Donata Orfei; Nerisa Banaj; Francesca Salani; Antonio Ciaramella; Carlo Caltagirone; Gianfranco Spalletta; Paola Bossù Objective: Interaction between the nervous and immune systems may influence emotions, ultimately affecting human health. Cytokines may...

... HC underwent a neurocognitive assessment for verbal memory by means of the revised Hopkins Verbal Learning Test (HVLT-R) in addition to serum cytokines analyses. Results: SZ patients performed worse in HVLT-R than SB and HC, but SB and HC were not different. Regarding the biomarker levels, we found...

... alterations in inflammatory markers, such as cytokines and chemokines, in patients with ASD and in the VPA animal model. [email protected] 8 05 2018 13 07 2018 29 8 2018 © 2018 S. Karger AG, Basel 2018 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

...Arão Belitardo Oliveira; Andre Luis Lacerda Bachi; Reinaldo Teixeira Ribeiro; Marco Túlio Mello; Mauro Vaisberg; Mario Fernando Prieto Peres Objective: To conduct a randomized controlled trial to evaluate the effect of a 12-week aerobic exercise program for migraine prevention, plasma cytokines...

... cytokines and metalloproteinases (MMPs) which participate in wound healing. These cells have a catecholaminergic system that modulates skin pathophysiologic processes. We have demonstrated that dopamine modulates cytokine production in keratinocytes via dopaminergic and adrenergic receptors (ARs). The aim...