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Keywords: Aging
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Neuroimmunomodulation (2010) 17 (3): 217–220.
Published Online: 04 February 2010
... during aging. Our results demonstrate that, despite the profound alterations observed in the thymic epithelial microenvironment of aged thymuses, the proportions of different CD4/CD8 thymocyte subsets do not undergo significant variations. Remarkably, a strong CXCL12 expression was found in older...
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Neuroimmunomodulation (2008) 15 (4-6): 323–330.
Published Online: 26 November 2008
...Nathan L. Sparkman; Rodney W. Johnson The aging brain is characterized by a shift from the homeostatic balance of inflammatory mediators to a proinflammatory state. This increase in neuroinflammation is marked by increased numbers of activated and primed microglia, increased steady-state levels...
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Neuroimmunomodulation (2008) 15 (4-6): 279–284.
Published Online: 26 November 2008
...Isabel Baeza; Carmen Alvarado; Carmen Ariznavarreta; Carmen Castillo; Jesús A.F. Tresguerres; Mónica De la Fuente Introduction: Age-related changes in the communication between the neuroendocrine and the immune system have been scarcely studied. Aging in mammals is associated with an impairment...
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Neuroimmunomodulation (2008) 15 (4-6): 351–364.
Published Online: 26 November 2008
...Gerald Pfister; Wilson Savino The continuous global increase in life expectancy represents a central challenge for our society and impacts public social security systems, families and individuals. One of the most striking changes that occur during normal human aging is immunosenescence...
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Neuroimmunomodulation (2008) 15 (4-6): 241–250.
Published Online: 26 November 2008
...Moisés Evandro Bauer This paper reviews recent work suggesting that human immunosenescence may be closely related to both chronic stress and stress hormones. The age-related immunological changes are also similarly found during chronic stress or glucocorticoid exposure. These data further suggest...
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Neuroimmunomodulation (2008) 15 (4-6): 213–223.
Published Online: 26 November 2008
...Mónica De la Fuente Aging is accompanied by an impairment of the physiological systems including the nervous, endocrine and immune systems, as well as of the nervous-immune communication. This impairment could explain the loss of homeostasis as well as the increased morbidity and mortality...
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Neuroimmunomodulation (2008) 15 (4-6): 251–259.
Published Online: 26 November 2008
...Jean-Philippe Gouin; Liisa Hantsoo; Janice K. Kiecolt-Glaser Aging is associated with a natural dysregulation in immune functioning which may be amplified when it occurs in the context of chronic stress. Family dementia caregiving provides an excellent model to study the impact of chronic stress...
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Neuroimmunomodulation (2003) 10 (6): 351–358.
Published Online: 15 August 2003
... patients (age range 55–82 years): 9 postmenopausal females (without hormone replacement therapy) and 6 males. The results (mean ± SEM) indicated that circulating leptin levels were significantly (p < 0.05) higher in female AD (40.34 ± 11.1 ng/ml) than in male AD (6.07 ± 1.39 ng/ml) patients...
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