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First page of Correlation analysis between serum NLRP1 inflammasome and depression in acute stage of stroke

Objective:To investigate the correlation between serum NLRP1 inflammasome level and depressive state in acute stage of stroke.Method:A total of 102 patients with acute stroke who were hospitalized for the first time in the Department of Neurology of the First Affiliated Hospital of Dali University from April 2023 to October 2023 were included, and 80 of them met the inclusion criteria. On the 7th day of admission, the patients were evaluated using the 24-item Hamilton Depression Scale (HAMD-24), and were divided into 31 patients in the acute stage of stroke depression group and 49 patients in the acute stage of stroke non-depression group. The general clinical data of patients were collected, the unified Stroke Scale score (NIHSS) and Pittsburgh Sleep Quality Index score (PSQI) were performed, and fasting serum was collected in the morning of the next day. NLRP1 inflammatory bodies (NLRP1, ASC, Caspase1) and inflammatory factors IL-1β, IL-18, IL-10, TNF-α were detected.Result:1. The incidence of depression in acute stage of stroke was 38.75%. 2. There were statistically significant differences in PSQI and NIHSS scores between the two groups (P < 0.05), and the scores were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (P < 0.05). 3. The expression levels of NLRP1, IL-18 and TNF-α in serum were significantly different between the two groups (P < 0.01), and the expression levels were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (P < 0.05). There were no significant differences in the expression levels of serum IL-1β, IL-10, Caspase-1 and ASC (P > 0.05). 4. Further analysis by stepwise fitting binary logistic regression showed that NIHSS score, NLRP1 and IL-18 level were independent risk factors for depression in acute stage of stroke (P < 0.05). 5. NIIHSS score, NLRP1 and IL-18 ROC curve area have certain predictive value for the occurrence and development of acute depression during stroke.Conclusion:The more severe the neurological impairment and sleep disorder, the higher the expression level of NLRP1 inflammasome in blood, and the more severe the depression in acute stage of stroke.

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2025
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