...Arend Bökenkamp; Michael Ludwig Following glomerular filtration, the bulk of solutes are reabsorbed in the proximal tubule to prevent excessive losses of vital metabolites. In this nephron segment, reabsorption is largely active via dedicated transporters. Hereditary defects in proximal tubular...

...A.M. Hall; M. Campanella; A. Loesch; M.R. Duchen; R.J. Unwin Background: The renal proximal tubule (PT) is clinically vulnerable to mitochondrial dysfunction; sub-lethal injury can lead to the Fanconi syndrome, with elevated urinary excretion of low-molecular-weight proteins. As the mechanism...

... reabsorption causes early diabetic hyperfiltration, while a heightened sensitivity of the proximal tubule to dietary salt leads to the so-called salt paradox, where a change in dietary salt causes a reciprocal change in GFR (‘tubulocentric principle’). Here, experiments were performed in adenosine A 1 receptor...

...Natalie Glube; Peter Langguth Background/Aims: Organic cation transporters (OCT) in the proximal tubules (PTs) participate in the renal secretion of several therapeutic agents. The exact role of OCT3 in renal secretion remains undetermined, partially due to the lack of an appropriate in vitro model...

... proportion of the fluid filtered at the glomerulus leaves the proximal tubule and enters Henle’s loop. Increased fluid flow in the thick ascending loop of Henle decreases the lumen-positive transepithelial potential difference, a driving force for any paracellular lithium reabsorption [ 23 ]. Therefore, our...

...-ATPase traffic. In contrast, Rab11 colocalized with V-ATPase in apical regions of proximal tubule, and Rab20 colocalized with the enzyme in intercalated cells. Rab11 and Rab20 were enriched in membrane fractions that were also enriched in V-ATPase B2 and B1 subunit isoforms, respectively. Conclusions...

... in Xenopus oocytes, Na/P i co-transport activity was demonstrated. In Northern blotting analysis, rNPT4 was selectively expressed in the liver and kidney. In immunohistochemical analysis, rNPT4 was localized at the apical membrane of the proximal tubules (S2, S3) in the rat kidney. The electron microscopic...