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Keywords: Pharmacological chaperone
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Journal Articles
Subject Area:
Nephron Physiology (2010) 114 (1): p1–p10.
Published Online: 08 October 2009
... 2 did not respond. In vitro analysis revealed a reduced cell surface expression and decreased binding affinity for arginine-vasopressin of the mutant receptor, leading to blunted signaling activity. Treatment with the pharmacological chaperone SR121463 enhanced cell surface expression. Conclusion...