... ischemia-reperfusion injury L-Arginine Prostaglandin E 1 Nitric oxide The renal ischemia-reperfusion injury is a complex inflammatory process that involves the vascular endothelium and activated leukocytes. During ischemia, the endothelium is primed to produce free radicals and to secrete chemo...

...Hiroshi Kamijo; Makoto Higuchi; Kazuhiko Hora Background: Nitric oxide (NO) is known to play a role in diabetic nephropathy, but the molecular basis for this effect remains unclear. Method: Otsuka Long-Evans Tokushima Fatty spontaneous diabetic rat models were used along with Long-Evans Tokushima...

...Selma Cirrik; Gülsen Öner Aim: This in vitro study using rat cortical slices, isolated proximal tubules and mitochondria was conducted to investigate the effect of exogenous and endogenous nitric oxide on ammoniagenesis. Methods and Results: The cortical slices were incubated with phosphate...

...Joseph Satriano; Mark J. Lortie; Shunji Ishizuka; José M. Valdivielso; Beth Friedman; Karen A. Munger Background/Aims: Inducible nitric oxide (NO) synthase (iNOS) generated NO increases in the early phase of Thy-1 glomerulonephritis concurrently with mesangiolysis and reduction in glomerular...

...Peter F. Mount; Scott A. Fraser; Yasuo Watanabe; Natalie Lane; Frosa Katsis; Zhi-Ping Chen; Bruce E. Kemp; David A. Power Background: Renal nitric oxide (NO) synthesis increases with increasing salt intake, however, the mechanisms underlying this are poorly understood. We hypothesized...

... of simvastatin (SIMV) in a model of hypertension and progressive renal disease, as well as its effects on the cyclin-cdk inhibitors p21 and p27. Methods: Munich-Wistar rats received the nitric oxide (NO) synthase inhibitor L -NAME (25 mg/kg/day p.o.) for 20 days accompanied by a high-salt diet (HS, 3% Na...

... preparations were studied for alterations in acetylcholine-induced dilatation and phenylephrine-induced contraction. It is well established that vasoactive prostanoids and nitric oxide (NO) generally play an important role in control of vascular tone in health and disease [ 9 ]. They are important mediators...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Tamm-Horsfall glycoprotein Peroxynitrite Nitric oxide S-nitrosothiol Total –CHO content Human urine is almost always supersaturated with a mixture of various ions...

...Yingwei Wang; Jianxia Tong; Renxian Tang; Hongyan Dong; Jinghua Xu Aims: To explore the effects of ligustrazine on proteinuria, urinary TxB 2 (metabolism of thromboxane A 2 , TxA 2 ) and 6-keto-PGF 1α (metabolism of prostacyclines I 2 , PG I 2 ), glomerular inducible nitric oxide(NO) synthase (iNOS...

... hemodynamic adaptations have not been definitively identified. Several investigators have postulated that nitric oxide (NO) is involved this physiological mechanisms. The purpose of this study was to evaluate the role of vascular and renal NO pathway in the model of subtotal nephrectomy-salt load hypertension...

... Poly(ADP-ribose) polymerase Medullary thick ascending limb Radiologic contrast media Prostaglandins Nitric oxide 3-Aminobenzamide Renal tubular cells, subjected to lethal hypoxic, toxic or oxidative stress, develop functional and structural changes that ultimately end with programmed cell...

...Eduardo Podjarny; Sidney Benchetrit; Mauro Rathaus; Avishalom Pomeranz; Gloria Rashid; Janice Shapira; Jacques Bernheim Background: Previous studies have shown that endothelial dysfunction after 5/6 nephrectomy (5/6 Nx) in rats is associated with decreased nitric oxide (NO) bioavailability...

...Yoshihiro Takamitsu; Takeshi Nakanishi; Futoshi Nishihara; Yukiko Hasuike; Masaaki Izumi; Toru Inoue; Keisuke Hiraoka; Reiko Itahana; Koji Miyagawa Background: The L- arginine-nitric oxide (NO) pathway plays an important role in the modulation of glomerular disease. We investigated whether β...