..., but was blunted in A 1 R–/–. A reciprocal relationship between GFR and dietary salt was found in WT diabetics, but not A 1 R–/– diabetics or nondiabetics of either strain. Conclusion: A 1 Rs determine glomerular hyperfiltration and the salt paradox in early diabetes, which is consistent with the tubulocentric...

... Progression of renal disease Glomerular hyperfiltration Glomerulosclerosis Tubulointerstitial fibrosis AT 1 and AT 2 receptors ANG II stimulates mRNA and protein expression of the chemokine RANTES, a member of the C-C chemokine subfamily with chemoattractant properties for monocytes/macrophages (M...