... involvement in depression, the focus was mostly on cortisol/corticosterone, whereas aldosterone appears to be the ‘forgotten' stress hormone. Part of the reason for this is that the receptors for aldosterone, the mineralocorticoid receptors (MR), were thought to be occupied by glucocorticoids in most parts...

...Carsten A. Wagner Aldosterone is classically associated with the regulation of salt and potassium homeostasis but has also profound effects on acid-base balance. During acidosis, circulating aldosterone levels are increased and the hormone acts in concert with angiotensin II and other factors...

.... Therefore, aldosterone participates in the phenotypical transformation of VSMCs. In preclinical models, aldosterone antagonism reduces vascular osteoinduction. Patients with CKD suffer from hyperphosphatemia predisposing to vascular osteogenic transformation, potentially further fostered by concomitant...

... the pathophysiology in conditions like salt-sensitive hypertension and chronic heart failure. Here we review the central role of the mineralocorticoid aldosterone in both the increase in renal salt reabsorption and sodium appetite. We discuss the working hypothesis that aldosterone activates similar signaling...

...Thomas B. Jensen; Trairak Pisitkun; Jason D. Hoffert; Uffe B. Jensen; Robert A. Fenton; Helle A. Praetorius; Mark A. Knepper; Jeppe Praetorius Background/Aims: Aldosterone exerts multiple long-term effects on the distal renal tubules. The aim of this study was to establish a method for identifying...

... is the principal site for regulating the rate of Na + efflux from the body and the mineralocorticoid hormone aldosterone plays a crucial role in regulating this process (fig. 1 ). Aldosterone promotes Na + reabsorption and net K + secretion through the regulation of membrane transporter activity. The overall...

... Fluid therapy Electrolyte disorders Dehydration Aldosterone Original Paper Nephron Physiol 2006;103:p164 p169 DOI: 10.1159/000092917 Received: April 14, 2005 Accepted: November 27, 2005 Published online: April 24, 2006 Study of Erythrocyte ATPases in Infants Evaluated during the Recovery Phase...

... of parathormone (PTH), it may also be exerted through regulation of profibrotic factors such as aldosterone. In adrenal cortex cell cultures, PTH increases aldosterone release. The objective of this work is to assess the effect of parathyroidectomy on aldosterone levels and on cardiac fibrosis and apoptosis...

...Farouk Markos; Vincent Healy; Brian J. Harvey Background: In this study, the mechanism of the rapid non-genomic effect of aldosterone on Na + /H + exchanger (NHE)-mediated intracellular pH (pH i ) recovery from an acid load in murine M-1 cortical collecting duct cells was assessed. Methods...

...Dierk H. Endemann; Konrad Wolf; Carsten A. Boeger; Günter A.J. Riegger; Bernhard K. Krämer Background: Aldosterone seems to play a role in the development of chronic renal failure and proteinuria. We investigated the adrenal aldosterone production and the adrenal renin-angiotensin system (RAS...

...Anette Fiebeler; Hermann Haller The mineralocorticoid receptor mediates the effects of aldosterone. In addition to its influence on fluid and electrolyte, aldosterone plays a role in cardiac hypertrophy, tissue fibrosis, and modulation of vascular reactivity. However, the intracellular signaling...