...Christoph Härtel; Angela Kribs; Wolfgang Göpel; Peter Dargaville; Egbert Herting Background: Less invasive surfactant administration (LISA) has become the preferred method of surfactant administration for spontaneously breathing babies on continuous positive airway pressure (CPAP). Summary...

...Ilari Kuitunen; Kati Räsänen Introduction: In spontaneously breathing neonates, surfactant can be administered via thin catheter while enabling the own breathing (less invasive surfactant administration [LISA]). Alternatively, the neonate is intubated for surfactant delivery (intubation, surfactant...

...) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline mutations are known to be associated with brain-lung thyroid syndrome. We report the case of a full-term neonate who developed refractory respiratory failure with pulmonary hypertension requiring...

...; Fabio Mosca; Carlo Dani; Eugenio Baraldi; Lucio Giordano; Peter G Davis; Letizia Capasso Introduction: Early targeted surfactant therapy for preterm infants is recommended but the best criteria to personalize treatment are unclear. We validate a previously published multivariate prognostic model based...

...Lina M.P. Kleijkers; Jooske Van Der Spil; Lobke C.E. Janssen; Jeanne P. Dieleman; Peter Andriessen; Anton H. van Kaam; Wes Onland; Hendrik J. Niemarkt Introduction: Less invasive surfactant administration (LISA) to preterm infants is associated with decreased risk for death or BPD. After LISA...

... of postmenstrual age, and we estimated the LUS evolution in each group with a linear multilevel mixed-effects regression model. The effects of the need for surfactant or an msBPD diagnosis were also studied. Results: We included 339 patients: 122 (36%) in group 1 and 217 (64%) in group 2. The infants in group 1...

...Jennifer Peterson; Maria C. den Boer; Charles Christoph Roehr Less invasive surfactant administration (LISA) is an effective, minimally invasive technique of administering surfactant to infants with respiratory distress syndrome. While termed less invasive, LISA still requires airway...

.... One of the main morbidities associated with extreme prematurity is bronchopulmonary dysplasia (BPD) [1], affecting up to 40% preterm infants under 28 weeks gestational age (GA) [2], with high variability among centers and geographic regions [3]. Antenatal steroids, early surfactant administration...

...Christoph Härtel; Kirsten Glaser; Christian P. Speer Surfactant replacement therapy (SRT) has long become the standard of care in the treatment of neonatal respiratory distress syndrome (RDS), significantly decreasing acute pulmonary morbidity and mortality in preterm infants. For decades...

...Doris Cunha-Goncalves; Anders Nord; Federico Bianco; Fabrizio Salomone; Francesca Ricci; Martin Schlun; Rikard Linner; Valeria Perez-de-Sa Introduction: The ideal body position during surfactant nebulization is not known. Objective: The aim of this study was to determine whether body positioning...

...Merja Kallio; Anne-Sea van der Zwaag; Andreas D. Waldmann; Marika Rahtu; Martijn Miedema; Thalia Papadouri; Anton H. van Kaam; Peter C. Rimensberger; Richard Bayford; Inéz Frerichs Background: Exogenous surfactant administration is an essential part of respiratory distress syndrome treatment...

...Barbara De Bisschop; Frank Derriks; Filip Cools The INtubation-SURfactant-Extubation (INSURE) procedure is a widely-used surfactant administration method to treat preterm infants with respiratory distress syndrome (RDS) but is not always successful. We conducted a systematic review to identify...

...Whittney D. Barkhuff; Roger F. Soll Traditionally, surfactant has been administered to preterm infants with respiratory distress syndrome via an endotracheal tube and in conjunction with mechanical ventilation. However, negative consequences of mechanical ventilation such as pneumothorax...

...Cornelia G. de Waal; Gerard J. Hutten; Frans H. de Jongh; Anton H. van Kaam Background: Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. Objectives...

... to prophylactic surfactant and treatment with mechanical ventilation. A number of infants treated with early nCPAP do not need treatment with surfactant, but few studies provide data on this. Since the 1990s, the first approach to respiratory support to preterm infants in Denmark has been early nCPAP combined...

...Christian A. Maiwald; Patrick Neuberger; Matthias Vochem; Christian Poets Background: Recent studies indicate an increasing use of less invasive surfactant administration. Different techniques have been shown with distinct risks and benefits. The aim of this study was to develop a new method...

... Study of Inhaled Steroids (NEUROSIS), including 863 very preterm infants (gestational age 23-27 weeks), have been presented at scientific conferences, but the full study report is not yet published [12]. By contrast, intratracheal instillation of budesonide using surfactant as a vehicle has not yet...

... to have some advantages compared to self-inflating bags. Surfactant instillation is often not needed prophylactically provided the mother has received antenatal steroids. Less invasive methods for administering surfactant may be useful. If ventilatory support is needed, start with air in term and near...

... of cardiac compressions (p < 0.01), use of a pressure of 30 cm H 2 O for sustained inflations (p < 0.05), and intubation in the delivery room (p < 0.01). After multivariate logistic regression only prenatal steroids (OR 0.41, 0.20-0.85), epinephrine (OR 3.56, 1.55-8.15) and surfactant use (OR 12.03...

...Rikard Linner; Valeria Perez-de-Sa; Doris Cunha-Goncalves Background: It would be advantageous for the treatment of neonatal respiratory distress syndrome if effective amounts of surfactant could be delivered by nebulization. Objective: To investigate lung deposition and distribution of nebulized...