..., it remains a question in KCNQ2 -related disorders that who will develop into atypical developmental outcomes. Methods: We established a prediction model for the neurodevelopmental outcomes of newborns with seizures caused by KCNQ2 gene defects based on the Gradient Boosting Machine (GBM) model...

...Wievineke M.J. Apers; Linda S. de Vries; Floris Groenendaal; Mona C. Toet; Lauren C. Weeke Introduction: Neonatal seizures are common and caused by a variety of underlying disorders. There is increasing evidence that neonatal seizures result in further brain damage. Objective: To describe the time...

... damage. Results: Out of 180 eligible patients 110 were randomized, 57 (51.8%) to topiramate and 53 (48.2%) to placebo. No differences in the perinatal or postnatal variables were found. The topiramate group exhibited less seizure burden in the first 24 h of hypothermia (topiramate, n = 14 [25.9%] vs...

.... Objectives/Methods: We report the clinical presentation of a preterm triplet infant delivered by elective cesarean who showed peripheral facial palsy immediately after birth. Results: Tonic seizures with high-voltage discharges over the contralateral cerebral hemisphere and secondary generalization were...

.... Results: No effect of therapeutic hypothermia on pharmacokinetics could be identified. Add-on seizure control with midazolam was limited (23% seizure control). An inverse relationship between the midazolam plasma concentration and mean arterial blood pressure could be identified. At least one hypotensive...

... prescriptions in NICU residents requires entries if any of the following symptoms occurred during the last 24 h: tachycardia (resting heart rate >200/min), clinical or encephalographic seizures, gastric residuals, vomiting, or necrotizing enterocolitis (NEC). ECC and LP were administered at identical doses...

... to this mishap so far. MRI scan performed after 4 months showed no evidence of cerebral complications including white matter injury. Even severe hypernatremia might not inevitably lead to central nervous system dysfunction and seizures in extremely low birth weight infants. © 2009 S. Karger AG, Basel 2009...

... neonates (pH > 7.15). Intraventricular hemorrhage (preterms) or seizures (both preterms and full-terms) were considered an adverse short-term outcome. Neonatal death, cerebral palsy or neurodevelopmental delay were considered an adverse long-term outcome. Results: Severe intraventricular hemorrhage (IVH...