... the protective effect of surfactant on intestinal cells in hypoxia-induced experimental NEC in rats. Methods: The study was performed on Sprague Dawley rat pups divided into three groups. Group 1 served as nonhypoxic controls (n = 15). Group 2 rats (untreated; n = 15) were subjected to hypoxia and reoxygenation...

...Samuel Ruiz; Victor Fernández; Jorge Belmar; Alejandro Hernández; Hernán Pérez; Miguel Sanhueza-Tsutsumi; Sergio Alarcón; Rubén Soto-Moyano The effect of chronic yohimbine treatment early in life on packing density of neurons was evaluated in the occipital cortex of young rats. Yohimbine...

... of venous blood flow towards the heart. The aim of this study was to determine the mechanism of action of this agent and to investigate whether a total β-adrenoceptor antagonist could reduce the fetoplacental disorders elicited in streptozotocin-diabetic pregnant rats. Diabetes was engendered on day 7.5...

...Fujio Kakuya; Masaru Shirai; Masashi Takase; Noriyuki Ishii; Akimasa Okuno Erythropoietin (EPO) levels in amniotic fluid and serum were measured in hypoxic (fraction of inspired oxygen, FiO 2 , 0.09) and posthypoxic (following a 24-hour period of hypoxia, FiO 2 0.09) fetal rats on day 21...

...Shi-Zeng Yuan; Mats Blennow; Michael Runold; Hugo Lagercrantz The aim of this study was to test the effects of glucose on the gasping ability and survival in a rat pup model during acute anoxia. Newborn rat pups of both 1 and 8 days of age were given glucose (30 and 60 mg/animal) or saline...

...Haruo Nogami; Toshiaki Tachibana; Hiroshi Ishikawa The effect of growth hormone (GH) on fetal growth was examined in the spontaneous dwarf rat (SDR) with the isolated GH deficiency. A 328-bp GH gene fragment containing the site of SDR mutation was amplified from fetal liver genomic DNA using PCR...

...D. Yamamoto; Y. Hiramatsu; K. Eguchi; T. Kudo The effects of epidermal growth factor (EGF) on ornithine decarboxylase (ODC) activity and DNA synthesis were studied during the perinatal period in rats. EGF administration to neonatal rats increased ODC activity and DNA synthesis in neonatal rat liver...

... activity, and urea and polyamine levels in livers of virgin and 21-day pregnant rats, either in a basal state or after the induction of ureagenesis by inducing diabetes in rats by streptozotocin injection. Diabetes led to a marked increase in circulating and liver urea levels in virgin rats. This response...

...Thor W.R. Hansen; Edward C. Maynard; William J. Cashore; William Oh To investigate the possible role of sepsis with endotoxemia in kernicterus, we studied the effect of endotoxin on accumulation of bilirubin and albumin in rat brain. Male Sprague-Dawley rats were given Escherichia coli endotoxin...

...Damir Sapunar; Mirna Saraga-Babić; Marijana Peruzović; Matko Marušić The aim of the study was to investigate the toxic effects of hyperbaric oxygen (HBO) on rat embryos. Two groups of Fischer pregnant rats were exposed to oxygen at pressures of 324 and 426 kPa for 90 min per day for 5 consecutive...

...Victor Fernández; Rodrigo Pascual; Samuel Ruíz Sprague-Dawley albino rats were subjected to an experimental paradigm in which environmental and nutritional variables were studied from birth to day 18. The use of Golgi-Cox-Sholl methodology allowed quantitative evaluations of neurons which were...

...Helmut Bräunlich; Mirko Schmidt Following treatment of rats of various age groups with calcitriol (2 µg/kg b.w., 3 days, once daily) renal tubular transport of p -aminohippurate (PAH) is reduced in kidney cortical slices prepared from 5-, 15-, 33-, and 55-day-old rats. The decrease in renal...

...Carmen Muñoz; Pilar López-Luna; Emilio Herrera To study insulin/glucose relationship during gestation, rats were studied on days 6, 12, 15, 18, 20 or 21 of pregnancy and the results were compared to values in sex-matched virgin control rats. Blood glucose levels were decreased on days 20 and 21...

... dysmorphogenesis and alterations in embryonic polyamine concentrations may contribute to this process. In the present study we have measured the contents of DNA, putrescine, spermidine and spermine in embryos on days 10 and 11 of gestation in normal and diabetic rats. We also estimated the activity of ornithine...

...S. Deloof; A. Chatelain; A. Leprêtre The effects of rat corticotropin-releasing factor (rCRF, 1.25 pmol/50 μl/fetus), arginine vasopressin (AVP, 5 pmol/50 μl/fetus) and oxytocin (OT, 12.5 pmol/50 μl/fetus) alone or in association were investigated in 21-day-old rat fetuses injected intravenously...

...G.S.G. Spencer; G.M. Robinson; C.J. Berry; P.M. Dobbie To study the effects of exogenous growth hormone (GH) administration to the mother on fetal growth, dwarf rats with an isolated GH deficiency were given daily s.c. injections of GH throughout pregnancy. Fetuses were heavier in GH-treated...

...-22 between these two groups, suggesting that amniotic fluid affects the development of the colonic goblet cells, especially during the period between days 19 and 21 when rat fetuses began to swallow amniotic fluid, as demonstrated by injecting India ink into the amniotic cavity. By immunological dot...

...S. Deloff; A. Leprêtre; V. Montel; A. Châtelain The effect of rat atrial natriuretic factor (rANF) on aldosterone and corticosterone secretion was investigated in vivo in 21-day-old rat fetuses injected intravenously through the umbilical vein and in vitro on isolated adrenal cells from 17-, 19...

...James E. Carroll; Byron S. McGuire; Valerie F. Chancey; Katherine B. Harrison Fatty acid oxidation rates tend to increase with age in most developing tissues. In skeletal muscle, heart, and liver of developing rats, we measured activities of three acyl-CoA dehydrogenase enzymes, which constitute...

...Ann-Maree Lynch; Neville W. Bruce Maternal hypoxemia has been associated with fetal-growth retardation and placental hypertrophy. Here, rats were exposed to carbon monoxide (CO), 100 ppm, at different stages of gestation to determine when during pregnancy placental hypertrophy can be elicited...