...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2022 Pharmacokinetics Ibuprofen Neonates Patent ductus arteriosus Pharmacology A hemodynamically significant...

.... The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diaphragmatic hernia Medication error Pharmacokinetics Sildenafil Neonate Sildenafil is often used to treat pulmonary hypertension (PH) in neonates. Efficacy...

... multiple small studies have reported the efficacy of doxapram, the structural co-treatment with caffeine impedes to ascribe the efficacy to doxapram itself or to a pharmacokinetic (PK) interaction where doxapram increases the exposure to caffeine. We examined whether there is a PK drug-drug interaction...

...-epileptic drug. Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrate. Therefore, co-treatment with phenobarbital might impact midazolam clearance. Objectives: To assess pharmacokinetics and clinical anti-epileptic effectiveness of phenobarbital and midazolam...

...Ana M. Lopez-Samblas; Jose A. Adams; Ronald N. Goldberg; Marlene W. Modi This study characterizes the pharmacokinetics of bumetanide after an intravenous dose of 0.05 or 0.10 mg/kgto 14neonates (weight range 820-4,000 g; gestational age 26-40 weeks) during the first week of life. Blood samples...

... and some have failed to show an effect with that dose. We determined the pharmacokinetics of furosemide administered directly to the airway in 7 young adult male guinea pigs who received intravenous and intratracheal doses of furosemide. Each animal received a 3 mg/kg i.v. bolus, 1, 3 and 6 mg/kg i.t. in 2...

...Ditsa Warszawski; Rafael Gorodischer; Shimon W. Moses; Hylton Bark The pharmacokinetics of caffeine were studied in young (age: 1 day, 7 days, 14 days, 30–45 days) and adult dogs following a single intravenous dose of 50 mg/kg. Mean ( ± SE) plasma elimination half life (T½ was 47.5 ( ± 5.35) h in 1...

...Marilyn J. Manco-Johnson; Michele R. Hacker; Linda J. Jacobson; William W. Hay, Jr. Background: The preterm infant is at risk for consumptive coagulopathy and thrombosis due to late maturation of coagulation regulatory proteins. Replacement proteins are available, but neonatal pharmacokinetic data...

... that systemic dosing of high-dose recombinant Epo (rEpo) would result in neuroprotective rEpo concentrations in the spinal fluid of adult and developing animals. This report characterizes the pharmacokinetics of high-dose rEpo in the blood and spinal fluid of juvenile and adult nonhuman primates (n = 7...

...Carlos Solans; Miguel Angel Bregante; José Javier Aramayona; Lorenzo José Fraile; María Angeles Garcia The pharmacokinetics of verapamil during ontogeny in rabbits and in vitro verapamil demethylase activity have been investigated in the liver and whole blood. In vivo experiments revealed...

...) deficiency to impede the development of emphysema. A1PI supplementation may also be useful for protecting premature neonates who receive mechanical ventilation from the development of chronic lung disease (CLD). However, the pharmacokinetics of exogenous A1PI in this population are unknown. We attempted...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Aminoglycosides Amikacin Neonates Preterm Dosing chart Pharmacokinetics Ototoxicity...

... Resources Service, School of Veterinary Medicine, c Facility for Advanced Instrumentation, and d Department of Anesthesiology, School of Medicine, University of California, Davis, Calif., USA OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Key Words Bupivacaine Obstetric anesthesia Pharmacokinetics Epidural...

...Nobuyasu Mizuno; Chie Takagi; Noriko Yamamoto; Koichi Takahashi The effect of cyclosporine A (CyA) on the pharmacokinetics of acyclovir in neonatal and adult rats was studied. CyA at 25 and 50 mg/kg for 2-week-old and adult rats, respectively, given as a subcutaneous injection, reduced growth...

...Vigna Rajan; Kay D.A. Beharry; Paul Williams; Houchang D. Modanlou The objective of this study was to determine hemodynamic effects and pharmacokinetic profiles of fentanyl with continuous infusion in 1- to 3-day-old newborn piglets. The piglets (n = 6) were administered a loading dose of fentanyl...