... Perinatal asphyxia Perinatal asphyxia followed by hypoxic-ischemic encephalopathy (HIE) is a severe neurological condition affecting 1–2 per 1,000 (near)term births in high-income countries [ 1 ]. It accounts for approximately 23% of the 4 million neonatal deaths worldwide [ 2 ] and is associated...

...Karianne B. Volstad; Are H. Pripp; Judith A. Ludviksen; Tom Stiris; Ola D. Saugstad; Tom E. Mollnes; Jannicke H. Andresen Introduction: Perinatal asphyxia initiates cytokine release and complement activation with risk of brain damage. We assessed the effect of nicotine on innate immunity...

... of preterm infants with perinatal asphyxia (PA) are underreported. We aimed to explore brain magnetic resonance imaging (MRI) findings and associated neurodevelopmental outcomes in these newborns. Methods: Retrospective multicenter study included infants with gestational age (GA) 24.0–36.0 weeks and PA...

... in umbilical cord blood (UCB) at birth, in cases with perinatal asphyxia with or without hypoxic-ischemic encephalopathy (HIE), compared with healthy controls and to assess their ability to predict HIE. Study Design: In this case-control study, term infants with perinatal asphyxia were recruited at birth. UCB...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Hypoxic-ischemic encephalopathy Perinatal asphyxia Hypothermia Erythropoietin Placenta Outcomes NIH Full-term and near-term neonates...

... Perinatal asphyxia Neonatal encephalopathy Therapeutic hypothermia (TH) is the single most effective intervention for decreasing both mortality (typical odds ratio [OR] 0.62 [95% credible interval: 0.46–0.83]) and neurodevelopmental delay at 18 months as a composite outcome (OR 0.48; 0.33–0.71...

..., instructions or products referred to in the content or advertisements. Neonate Apgar Perinatal asphyxia Hypoxic-ischemic encephalopathy Therapeutic hypothermia Meta-Analysis Neonatology 2022;119:669 685 DOI: 10.1159/000525926 Received: May 11, 2022 Accepted: July 1, 2022 Published online: August...

... kidney injury Therapeutic hypothermia Newborn Perinatal asphyxia Creatinine Precision medicine Reference values Perinatal asphyxia is a condition at delivery, caused by oxygen deprivation. When sufficiently long or severe, this can result in neonatal encephalopathy (NE) and subsequent...

...Ira Winkler; Tatjana Heisinger; Marlene Hammerl; Eva Huber; Martina Urbanek; Ursula Kiechl-Kohlendorfer; Elke Griesmaier; Anna Posod Introduction: Perinatal asphyxia is a leading cause of neonatal death. Up to one-third of asphyxiated neonates suffer from hypoxic-ischaemic encephalopathy (HIE...

... and post-injury recovery. Objectives: We previously showed that perinatal asphyxia (PA) induces hippocampal neuroinflammation and injury that are subject to epigenetic change by maternal diet. The present study investigates maternal citicoline-supplemented diet (CSD) impact on offspring hippocampal...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Neonatal encephalopathy Therapeutic hypothermia Neurodevelopment Perinatal asphyxia Neuromonitoring Neonatal encephalopathy (NE) due to presumed perinatal asphyxia is one...

... to in the content or advertisements. Brain injury Hypoxia-ischemia Hypoxic-ischemic brain injury Inflammation Mice Newborn brain Perinatal asphyxia Perinatal brain damage Despite increased knowledge and the introduction of hypothermia in the treatment algorithm, neonatal hypoxic-ischemic (HI...

... of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. Objectives: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. Methods: In a retrospective cohort of 1,084 infants with perinatal...

...-lasting inflammation. During pregnancy, HFD can induce developmental changes. Moreover, HFD-related maternal obesity might enhance the risk of peripartum complications including hypoxic-ischemic encephalopathy secondary to perinatal asphyxia (PA). Objectives: Following our previous results showing that PA...

... on the predictive value of TS in newborns undergoing therapeutic hypothermia to estimate long-term outcome is limited. Objectives: To determine the predictive value of TS to estimate long-term cognitive and neurological outcome in newborns with perinatal asphyxia treated with controlled hypothermia. Methods: Thirty...

...Ken Imai; Linda S. de Vries; Thomas Alderliesten; Nienke Wagenaar; Niek E. van der Aa; Maarten H. Lequin; Manon J.N.L. Benders; Ingrid C. van Haastert; Floris Groenendaal Background: Magnetic resonance imaging (MRI) is the standard neuroimaging technique to assess perinatal asphyxia-associated...

...Lauren C. Weeke; Ana Vilan; Mona C. Toet; Ingrid C. van Haastert; Linda S. de Vries; Floris Groenendaal Background: In previous studies clinical signs or amplitude-integrated electroencephalography (aEEG)-based signs of encephalopathy were used to select infants with perinatal asphyxia...

... the relationship between Epo, VEGF levels, brain injury and outcome in a group of term infants exposed to perinatal asphyxia (PA) compared to controls. Methods: Serum and CSF biomarkers associated with hypoxia (VEGF, Epo) were serially measured using multiplex immunoassays over days 1-4 in term infants exposed...

...Torkil Benterud; Martin B. Ystgaard; Sophia Manueldas; Leonid Pankratov; Clara Alfaro-Cervello; Geir Florholmen; Muhammad Shakil Ahmed; Leiv Sandvik; Svante Norgren; Magnar Bjørås; Lars O. Baumbusch; Ronnaug Solberg; Ola Didrik Saugstad Background: Perinatal asphyxia and ensuing reoxygenation...

... for the prediction of hypoxic-ischaemic encephalopathy (HIE) severity. Objective: To evaluate whether this metabolite score can predict 3-year neurodevelopmental outcome in infants with perinatal asphyxia and HIE, compared with current standard biochemical and clinical markers. Methods: From September 2009 to June...